Curr Diab Rep (2017) 17:86 DOI 10.1007/s11892-017-0925-9 IMMUNOLOGY, TRANSPLANTATION, AND REGENERATIVE MEDICINE (L PIEMONTI AND V SORDI, SECTION EDITORS) Heterogeneity in the Beta-Cell Population: a Guided Search Into Its Significance in Pancreas and in Implants 1 1 1 1 Daniel Pipeleers & Ines De Mesmaeker & Thomas Robert & Freya Van Hulle The Author(s) 2017. This article is an open access publication Abstract Introduction Purpose of Review Intercellular differences in function have since long been noticed in the pancreatic beta-cell population. The co-existence of functionally diverse beta-cell subpopula- Heterogeneity in cellular glucose responsiveness is considered tions was described 30 years ago and proposed to provide of physiological and pathological relevance. The present re- complementarity in functions . Subsequent studies led to view updates evidence for the physiologic significance of the concept of a functional heterogeneity in the beta-cell pop- beta-cell heterogeneity in the pancreas. It also briefly dis- ulation that determines its physiologic role, that is altered in cusses what this role would imply for beta-cell implants in physiological and pathological conditions, and that explains diabetes. differential impairment of beta-cell survival and function in Recent Findings Over the past 3 years, functionally different diabetes [2–4]. Supporting data were referred
Current Diabetes Reports – Springer Journals
Published: Aug 15, 2017
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