Gastric Cancer (2017) 20:772–783 DOI 10.1007/s10120-017-0692-y ORIGINAL ARTICLE Heterodimeric interaction between GKN2 and TFF1 entails synergistic antiproliferative and pro-apoptotic effects on gastric cancer cells 1 1 1 2 • • • • Olga Kim Jung Hwan Yoon Won Suk Choi Hassan Ashktorab 2 1 1 1 • • • Duane T. Smoot Suk Woo Nam Jung Young Lee Won Sang Park Received: 17 August 2016 / Accepted: 14 January 2017 / Published online: 1 February 2017 The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2017 Abstract regulators. Simultaneous knockdown of GKN2 and TFF1 Background GKN2 and TFF1 form a heterodimer that is in HFE-145 cells resulted in markedly increased cell via- only generated in the mucus-secreting cells of the normal bility. Moreover, the interaction of GKN2 and TFF1 pro- stomach. The formation of this heterodimer is frequently moted cell death by enhancing caspase-3/7 activity and disrupted in gastric cancer. However, the precise roles of upregulating pro-apoptotic proteins. At the mRNA level, GKN2 alone and in the heterodimer with TFF1 as well as GKN2 and TFF1 were found to be positively correlated in the contributions of GKN2 and the heterodimer to gastric non-tumor and tumor samples. Immunohistochemistry
Gastric Cancer – Springer Journals
Published: Feb 1, 2017
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