Heterocyclization and functionalization of 1,2-bis-(4-amino-5-mercapto-1,2,4-triazol-3-yl)benzene

Heterocyclization and functionalization of 1,2-bis-(4-amino-5-mercapto-1,2,4-triazol-3-yl)benzene 1,2-Bis(4-amino-5-mercapto-1,2,4-triazol-3-yl)benzene (3) was synthesized from the reaction of phthalic acid with thiocarbohydrazide. Reaction of 3 with ethylbromoactate or ethylchloroacetate afforded compound 4. Heating of 3 with chloroacetyl chloride or chloroacetic acid gave triazolothiadiazinone 5 and 8, respectively. Refluxing of 3 with phenacyl bromide resulted in benzoylmethylthiotriazole 9. Treatment of 3 with chloroacetamide or benzyl chloride yielded 11 and 13, respectively. Condensation of 3 with benzaldehyde or m-nitrobenzaldehyde gave the products 14a and 14b in the ratio 1:2, and 15, respectively. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Heterocyclization and functionalization of 1,2-bis-(4-amino-5-mercapto-1,2,4-triazol-3-yl)benzene

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Springer Netherlands
Copyright © 2013 by Springer Science+Business Media Dordrecht
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
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