Pediatric Radiology (2018) 48:451–452 https://doi.org/10.1007/s00247-017-4046-z Published online: 15 February 2018 Springer-Verlag GmbH Germany, part of Springer Nature 2017 MIBG avidity correlates with clinical features, tumor bi- (eRMS) is the most common subtype of RMS accounting ology, and outcomes in neuroblastoma: a report from the for approximately 49% of all RMS. Patients with metastatic Children’s Oncology Group RMS have a poor prognosis apart from children with eRMS DuBois SG, Mody R, Naranjo A et al whose metastases are confined to the lungs. The patients in Pediatr Blood Cancer (2017) 64:e26545 this study were analysed with a focus on response to induction chemotherapy. Response at week 7–10 was based on anatom- The authors compared the clinical and biologic features, ic imaging (chest CT) and determined for pulmonary metas- and clinical outcomes between patients with MIBG non- tases as a complete response with disappearance of all lesions avid and MIBG-avid neuroblastoma. The patient cohorts (pCR) or no complete response (no-pCR). Event-free (EFS) were taken from metastatic high- and intermediate-risk and overall (OS) survival were the endpoints. pCR at week 7– neuroblastoma COG studies. Lower-risk tumors such as 10 and the addition of maintenance therapy were favourable ganglioneuroma and ganglioneuroblastoma have been prognostic
Pediatric Radiology – Springer Journals
Published: Feb 22, 2018
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