Hereditary Muscular Dystrophy: Bioengineering Approaches to Muscle Fiber Repair

Hereditary Muscular Dystrophy: Bioengineering Approaches to Muscle Fiber Repair Restoration of disturbed functions of the organs and tissues is the main task of contemporary genetic and cellular biotechnology, including genetic and cellular therapy. Duchenne dystrophy, one of the most widespread human genetic diseases, is at the same time the most extensively studied from the viewpoint of both genetic and histological changes leading to muscle fiber degeneration. Although many studies carried out on models, recognized analogous to Duchenne dystrophy, gave hopeful results, clinical tests with the use of developed methods gave no expected success and the rate of mortality from this disease amounts to 100%. Based on the world experience and analysis of the authors’ data, possible influence of the intensity of regeneration on success of genetic and cellular therapy has been considered. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Developmental Biology Springer Journals

Hereditary Muscular Dystrophy: Bioengineering Approaches to Muscle Fiber Repair

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Publisher
Springer Journals
Copyright
Copyright © 2005 by MAIK “Nauka/Interperiodica”
Subject
Life Sciences; Developmental Biology; Animal Anatomy / Morphology / Histology
ISSN
1062-3604
eISSN
1608-3326
D.O.I.
10.1007/s11174-005-0041-7
Publisher site
See Article on Publisher Site

Abstract

Restoration of disturbed functions of the organs and tissues is the main task of contemporary genetic and cellular biotechnology, including genetic and cellular therapy. Duchenne dystrophy, one of the most widespread human genetic diseases, is at the same time the most extensively studied from the viewpoint of both genetic and histological changes leading to muscle fiber degeneration. Although many studies carried out on models, recognized analogous to Duchenne dystrophy, gave hopeful results, clinical tests with the use of developed methods gave no expected success and the rate of mortality from this disease amounts to 100%. Based on the world experience and analysis of the authors’ data, possible influence of the intensity of regeneration on success of genetic and cellular therapy has been considered.

Journal

Russian Journal of Developmental BiologySpringer Journals

Published: Aug 15, 2005

References

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