Hepatoprotective and hematoprotective effects of Falcaria vulgaris aqueous extract against CCl4-induced hepatic injury in mice

Hepatoprotective and hematoprotective effects of Falcaria vulgaris aqueous extract against... Medicinal plants are considered as modern resources for producing agents that could act as alternatives to chemical drugs. Falcaria vulgaris (FV) has been used in medicine as an antioxidant, antifungal, anti-inflammatory, and antibacterial agent. The aim of the present study was to investigate the hepatoprotective and hematoprotective effects of FVaqueous extract against CCl -induced hepatotoxicity in mice. Sixty male mice were divided into six groups (n = 10); group I served as control, received 1 mL/kg olive oil intraperitoneally and 0.5 mL distilled water through gavage. Group II served as untreated group, received 1 mg/ kg CCl mixed with olive oil in the ratio of 5:5 intraperitoneally and 0.5 mL distilled water orally. Groups III, IV, V, and VI received CCl mixed with olive oil in the ratio of 5:5 intraperitoneally and 20, 40, 80, and 160 mg/kg of FV aqueous extract through gavage for 45 consecutive days. Different doses of FV (especially FV160) could significantly (p ≤ 0.05) decrease the raised levels of alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, cholesterol, low-density lipoprotein, white blood cell, and platelet and increase high-density lipoprotein, superoxide dismutase, catalase, and red blood cell as compared to the untreated group. The weight and volume http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Hepatoprotective and hematoprotective effects of Falcaria vulgaris aqueous extract against CCl4-induced hepatic injury in mice

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Publisher
Springer London
Copyright
Copyright © 2018 by Springer-Verlag London Ltd., part of Springer Nature
Subject
Medicine & Public Health; Pathology; Hematology; Oncology
eISSN
1618-565X
D.O.I.
10.1007/s00580-018-2747-9
Publisher site
See Article on Publisher Site

Abstract

Medicinal plants are considered as modern resources for producing agents that could act as alternatives to chemical drugs. Falcaria vulgaris (FV) has been used in medicine as an antioxidant, antifungal, anti-inflammatory, and antibacterial agent. The aim of the present study was to investigate the hepatoprotective and hematoprotective effects of FVaqueous extract against CCl -induced hepatotoxicity in mice. Sixty male mice were divided into six groups (n = 10); group I served as control, received 1 mL/kg olive oil intraperitoneally and 0.5 mL distilled water through gavage. Group II served as untreated group, received 1 mg/ kg CCl mixed with olive oil in the ratio of 5:5 intraperitoneally and 0.5 mL distilled water orally. Groups III, IV, V, and VI received CCl mixed with olive oil in the ratio of 5:5 intraperitoneally and 20, 40, 80, and 160 mg/kg of FV aqueous extract through gavage for 45 consecutive days. Different doses of FV (especially FV160) could significantly (p ≤ 0.05) decrease the raised levels of alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, cholesterol, low-density lipoprotein, white blood cell, and platelet and increase high-density lipoprotein, superoxide dismutase, catalase, and red blood cell as compared to the untreated group. The weight and volume

Journal

Comparative Clinical PathologySpringer Journals

Published: May 28, 2018

References

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