Hepatitis-B immune globulin

Hepatitis-B immune globulin Reactions 1680, p158 - 2 Dec 2017 Development of viral resistance during treatment hepatitis B infection: case report In a study, a 2-month-old girl developed resistance to hepatitis-B immune globulin [dosage not stated] for hepatitis B infection. The girl was born to a hepatitis B virus (HBV) carrier mother and was administered IM injection of hepatitis-B immune globulin after birth. HBsAg level in the umbilical cord blood was found to be positive. At 1 month of age, her serum HBsAg level was 0.23 IU/mL, anti-HBs level was 13.22 IU/L and HBV- DNA in blood was 3.2 × 10 copies/mL. She started receiving repeated hepatitis-B immune globulin continuously as an immunoprophylaxis, to eliminate HBV. At 2 months of age, her serum HBsAg level became negative. However, after 10 months, HBsAg became detectable with increased blood HBV-DNA level. Eight months following vaccinations and after four hepatitis-B immune globulin injections, G145R mutation in the S gene of HBV genome was noted, which might be induced by hepatitis-B immune globulin treatment. The G145R strain became predominant at 10 months of age and she developed overt HBV infection [outcome not stated]. Author comment: "The aim of this study was to determine the OBI prevalence in such children in Japan and identify the genomic mutations that might be associated with the pathogenesis of OBI in children." "Of these two children, one received repeated hepatitis B immunoglobulin (HBIG) and developed overt HBV infection. Her HBV genome had a G145R mutation in the S gene that might have been induced by HBIG treatment." Yokoyama K, et al. Occult hepatitis B virus infection in immunized children born to carrier mothers. Pediatrics International 59: 1010-1016, No. 9, Sep 2017. Available from: URL: http://doi.org/10.1111/ped.13352 - Japan 803284721 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Hepatitis-B immune globulin

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-017-39089-3
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p158 - 2 Dec 2017 Development of viral resistance during treatment hepatitis B infection: case report In a study, a 2-month-old girl developed resistance to hepatitis-B immune globulin [dosage not stated] for hepatitis B infection. The girl was born to a hepatitis B virus (HBV) carrier mother and was administered IM injection of hepatitis-B immune globulin after birth. HBsAg level in the umbilical cord blood was found to be positive. At 1 month of age, her serum HBsAg level was 0.23 IU/mL, anti-HBs level was 13.22 IU/L and HBV- DNA in blood was 3.2 × 10 copies/mL. She started receiving repeated hepatitis-B immune globulin continuously as an immunoprophylaxis, to eliminate HBV. At 2 months of age, her serum HBsAg level became negative. However, after 10 months, HBsAg became detectable with increased blood HBV-DNA level. Eight months following vaccinations and after four hepatitis-B immune globulin injections, G145R mutation in the S gene of HBV genome was noted, which might be induced by hepatitis-B immune globulin treatment. The G145R strain became predominant at 10 months of age and she developed overt HBV infection [outcome not stated]. Author comment: "The aim of this study was to determine the OBI prevalence in such children in Japan and identify the genomic mutations that might be associated with the pathogenesis of OBI in children." "Of these two children, one received repeated hepatitis B immunoglobulin (HBIG) and developed overt HBV infection. Her HBV genome had a G145R mutation in the S gene that might have been induced by HBIG treatment." Yokoyama K, et al. Occult hepatitis B virus infection in immunized children born to carrier mothers. Pediatrics International 59: 1010-1016, No. 9, Sep 2017. Available from: URL: http://doi.org/10.1111/ped.13352 - Japan 803284721 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680

Journal

Reactions WeeklySpringer Journals

Published: Dec 2, 2017

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