Reactions 1680, p158 - 2 Dec 2017 Development of viral resistance during treatment hepatitis B infection: case report In a study, a 2-month-old girl developed resistance to hepatitis-B immune globulin [dosage not stated] for hepatitis B infection. The girl was born to a hepatitis B virus (HBV) carrier mother and was administered IM injection of hepatitis-B immune globulin after birth. HBsAg level in the umbilical cord blood was found to be positive. At 1 month of age, her serum HBsAg level was 0.23 IU/mL, anti-HBs level was 13.22 IU/L and HBV- DNA in blood was 3.2 × 10 copies/mL. She started receiving repeated hepatitis-B immune globulin continuously as an immunoprophylaxis, to eliminate HBV. At 2 months of age, her serum HBsAg level became negative. However, after 10 months, HBsAg became detectable with increased blood HBV-DNA level. Eight months following vaccinations and after four hepatitis-B immune globulin injections, G145R mutation in the S gene of HBV genome was noted, which might be induced by hepatitis-B immune globulin treatment. The G145R strain became predominant at 10 months of age and she developed overt HBV infection [outcome not stated]. Author comment: "The aim of this study was to determine the OBI prevalence in such children in Japan and identify the genomic mutations that might be associated with the pathogenesis of OBI in children." "Of these two children, one received repeated hepatitis B immunoglobulin (HBIG) and developed overt HBV infection. Her HBV genome had a G145R mutation in the S gene that might have been induced by HBIG treatment." Yokoyama K, et al. Occult hepatitis B virus infection in immunized children born to carrier mothers. Pediatrics International 59: 1010-1016, No. 9, Sep 2017. Available from: URL: http://doi.org/10.1111/ped.13352 - Japan 803284721 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680
Reactions Weekly – Springer Journals
Published: Dec 2, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera