Heparin

Heparin Reactions 1704, p183 - 2 Jun 2018 Spontaneous perirenal haematoma: case report In a case series of three patients , a 45-year-old woman was described, who developed spontaneous peri-renal haematoma during treatment with heparin [route and duration of treatment to reaction onset not stated; indication not clearly stated]. The woman had underlying condition of end stage renal disease (ESRD) due to hypertension. She received haemodialysis (HD) twice a week for six months and also received heparin 0.5 mg/kg (at 5 mg/hr) treatment during haemodialysis. However, she presented with an acute abdominal pain during haemodialysis session and and had to stop therapy before schedule on 4 June 2013. Physical examination was consistent with left abdominal tenderness. After several clinical investigations, an urgent CT scan revealed a large haematoma encroaching on the left kidney with ascites. A diagnosis of SPH was made. The woman’s heparin treatment was discontinued. Further HD was carried out without heparin. She underwent left renal artery gelatin sponge embolisation. She was treated with haemostatics, antibiotics, blood transfusion and haemodialysis. She exhibited complete recovery, and was discharged from the hospital after 10 days. Author comment: "In this article, we report a total of three cases of [spontaneous perirenal hemorrhage] in HD patients treated with selective renal arterial embolization." "Anticoagulation used for hemodialysis and uremia associated functional platelet abnormalities probably act as contributing factors." * Suspect drugs were not specified in other 2 patients. Both received an unspecified low-molecular-weight heparin. Xie Y, et al. Spontaneous perirenal hemorrhage in hemodialysis patient treated with selective embolization: A case series and review of the literature. Hemodialysis International 22: 222-227, No. 2, Apr 2018. Available from: URL: http://doi.org/10.1111/hdi.12607 - China 803323157 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Heparin

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46826-6
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p183 - 2 Jun 2018 Spontaneous perirenal haematoma: case report In a case series of three patients , a 45-year-old woman was described, who developed spontaneous peri-renal haematoma during treatment with heparin [route and duration of treatment to reaction onset not stated; indication not clearly stated]. The woman had underlying condition of end stage renal disease (ESRD) due to hypertension. She received haemodialysis (HD) twice a week for six months and also received heparin 0.5 mg/kg (at 5 mg/hr) treatment during haemodialysis. However, she presented with an acute abdominal pain during haemodialysis session and and had to stop therapy before schedule on 4 June 2013. Physical examination was consistent with left abdominal tenderness. After several clinical investigations, an urgent CT scan revealed a large haematoma encroaching on the left kidney with ascites. A diagnosis of SPH was made. The woman’s heparin treatment was discontinued. Further HD was carried out without heparin. She underwent left renal artery gelatin sponge embolisation. She was treated with haemostatics, antibiotics, blood transfusion and haemodialysis. She exhibited complete recovery, and was discharged from the hospital after 10 days. Author comment: "In this article, we report a total of three cases of [spontaneous perirenal hemorrhage] in HD patients treated with selective renal arterial embolization." "Anticoagulation used for hemodialysis and uremia associated functional platelet abnormalities probably act as contributing factors." * Suspect drugs were not specified in other 2 patients. Both received an unspecified low-molecular-weight heparin. Xie Y, et al. Spontaneous perirenal hemorrhage in hemodialysis patient treated with selective embolization: A case series and review of the literature. Hemodialysis International 22: 222-227, No. 2, Apr 2018. Available from: URL: http://doi.org/10.1111/hdi.12607 - China 803323157 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References

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