Heparin

Heparin Reactions 1704, p179 - 2 Jun 2018 Haemorrhage secondary to access-site haematoma: case report In an observational single centre study of 41 patients, a patient [age and sex not stated] was described, who developed moderate haemorrhage secondary to access-site haematoma during treatment with heparin [unfractionated heparin; dosage not stated]. The patient, who had acute submassive pulmonary embolism and was planned to undergo ultrasound-assisted catheter-directed thrombolysis (USAT). The patient was in delayed USAT group and received USAT after 24 hours of diagnosis. The patient was administered IV heparin bolus dose of 80 IU/kg followed by infusion with a targeted activated partial thromboplastin time of 1.5 to 2 times the laboratory control. During and after the procedure, IV heparin was continued and was closely monitored in the cardiovascular ICU. However, the patient developed moderate haemorrhage secondary to access-site haematoma. The patient received treatment with 2 units of packed RBCs [time to reaction onset and outcome not stated]. Author comment: "[T]he goal of our study was to evaluate the association of early use of USAT (≤24 hours from diagnosis) vs delayed use of USAT (>24 hours from diagnosis)". "There were no deaths and no severe or life- threatening bleeding as defined by the GUSTO definition among any of the 41 patients . . . 1 patient in the delayed- USAT group), each related to access-site hematomas and requiring 2 units of packed red blood cells." Edla S, et al. Early Versus Delayed Use of Ultrasound-Assisted Catheter-Directed Thrombolysis in Patients with Acute Submassive Pulmonary Embolism. Journal of Invasive Cardiology 30: 157-162, No. 5, May 2018. Available from: URL: https:// www.ncbi.nlm.nih.gov/pubmed/29715164 - USA 803323616 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Heparin

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46822-6
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p179 - 2 Jun 2018 Haemorrhage secondary to access-site haematoma: case report In an observational single centre study of 41 patients, a patient [age and sex not stated] was described, who developed moderate haemorrhage secondary to access-site haematoma during treatment with heparin [unfractionated heparin; dosage not stated]. The patient, who had acute submassive pulmonary embolism and was planned to undergo ultrasound-assisted catheter-directed thrombolysis (USAT). The patient was in delayed USAT group and received USAT after 24 hours of diagnosis. The patient was administered IV heparin bolus dose of 80 IU/kg followed by infusion with a targeted activated partial thromboplastin time of 1.5 to 2 times the laboratory control. During and after the procedure, IV heparin was continued and was closely monitored in the cardiovascular ICU. However, the patient developed moderate haemorrhage secondary to access-site haematoma. The patient received treatment with 2 units of packed RBCs [time to reaction onset and outcome not stated]. Author comment: "[T]he goal of our study was to evaluate the association of early use of USAT (≤24 hours from diagnosis) vs delayed use of USAT (>24 hours from diagnosis)". "There were no deaths and no severe or life- threatening bleeding as defined by the GUSTO definition among any of the 41 patients . . . 1 patient in the delayed- USAT group), each related to access-site hematomas and requiring 2 units of packed red blood cells." Edla S, et al. Early Versus Delayed Use of Ultrasound-Assisted Catheter-Directed Thrombolysis in Patients with Acute Submassive Pulmonary Embolism. Journal of Invasive Cardiology 30: 157-162, No. 5, May 2018. Available from: URL: https:// www.ncbi.nlm.nih.gov/pubmed/29715164 - USA 803323616 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

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