Hemolysis in Alcoholic Liver Disease: Zieve’s Syndrome

Hemolysis in Alcoholic Liver Disease: Zieve’s Syndrome Digestive Diseases and Sciences (2018) 63:601–604 https://doi.org/10.1007/s10620-018-4938-2 UNM CLINIC AL C ASE CONFERENCES 1 1 1 1 Anas Gremida  · Swathi Paleti  · Euriko Torrazza Perez  · Denis McCarthy Published online: 30 January 2018 © Springer Science+Business Media, LLC, part of Springer Nature 2018 Keywords Zieve’s syndrome · Hemolysis · Alcohol · Alcoholic liver disease · Hepatitis · Maddrey’s discriminant function Case Report 10.0 mg/dl, lactate dehydrogenase 400 U/l (100–190 U/l), lipase 285 mg/dl (10–73 mg/dl), triglycerides 208 mg/dl A 46-year-old female with history of asthma, hyperlipi- (<  150  mg/dl), cholesterol 275  mg/dl ethanol 65  mg/dl, demia, and heavy alcohol intake was initially evaluated for and direct anti-globulin test (Coombs test) was negative. the complaint of abdominal pain for 1 week, described as Serum haptoglobin was undetectable (20–240 mg/dl), and generalized, aching, constant, nonradiating, and associated international normalized ratio (INR) was 1.7 (0.5–1.1). A with lassitude, nausea, vomiting, and diminished appetite. peripheral blood smear showed spur cells, schistocytes, and She also noticed darkening of her urine over the same time. prominent macrocytosis. A stool test was negative for occult The patient denied any overt upper or lower gastrointestinal blood. Abdominal ultrasound with Doppler flow measure - bleeding and reported no changes in her mental status. The ment showed patent vasculature, increased liver echogenic- patient had consumed about http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Digestive Diseases and Sciences Springer Journals

Hemolysis in Alcoholic Liver Disease: Zieve’s Syndrome

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Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Gastroenterology; Hepatology; Oncology; Transplant Surgery; Biochemistry, general
ISSN
0163-2116
eISSN
1573-2568
D.O.I.
10.1007/s10620-018-4938-2
Publisher site
See Article on Publisher Site

Abstract

Digestive Diseases and Sciences (2018) 63:601–604 https://doi.org/10.1007/s10620-018-4938-2 UNM CLINIC AL C ASE CONFERENCES 1 1 1 1 Anas Gremida  · Swathi Paleti  · Euriko Torrazza Perez  · Denis McCarthy Published online: 30 January 2018 © Springer Science+Business Media, LLC, part of Springer Nature 2018 Keywords Zieve’s syndrome · Hemolysis · Alcohol · Alcoholic liver disease · Hepatitis · Maddrey’s discriminant function Case Report 10.0 mg/dl, lactate dehydrogenase 400 U/l (100–190 U/l), lipase 285 mg/dl (10–73 mg/dl), triglycerides 208 mg/dl A 46-year-old female with history of asthma, hyperlipi- (<  150  mg/dl), cholesterol 275  mg/dl ethanol 65  mg/dl, demia, and heavy alcohol intake was initially evaluated for and direct anti-globulin test (Coombs test) was negative. the complaint of abdominal pain for 1 week, described as Serum haptoglobin was undetectable (20–240 mg/dl), and generalized, aching, constant, nonradiating, and associated international normalized ratio (INR) was 1.7 (0.5–1.1). A with lassitude, nausea, vomiting, and diminished appetite. peripheral blood smear showed spur cells, schistocytes, and She also noticed darkening of her urine over the same time. prominent macrocytosis. A stool test was negative for occult The patient denied any overt upper or lower gastrointestinal blood. Abdominal ultrasound with Doppler flow measure - bleeding and reported no changes in her mental status. The ment showed patent vasculature, increased liver echogenic- patient had consumed about

Journal

Digestive Diseases and SciencesSpringer Journals

Published: Jan 30, 2018

References

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