Mammalian Genome 12, 77–79 (2001). DOI: 10.1007/s003350010235 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2001 Hemimelic extra toes and Hammer toe are distinct mutations that show a genetic interaction 1 2 1 1 1 Henk C. Heus, Anton J.M. Luijsterburg, Marijke J. van Baren, Guido J. Breedveld, Marijke N. Joosse, 1 2 1 1 Ingeborg M. Nieuwenhuizen, Christl Vermeij-Keers, Ben A. Oostra, Peter Heutink Department of Clinical Genetics, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands Department of Plastic and Reconstructive Surgery, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands Received: 30 May 2000 / Accepted: 11 September 2000 The mutations underlying the mouse Hemimelic extra toes (Hx) FeJLe-a/a-Ca background of the Hm mouse. After ten generations phenotype, characterized by preaxial polydactyly and shortening the phenotype was stable, with all heterozygous Hx mutant mice of the tibia, and the Hammer toe (Hm) phenotype, characterized by showing preaxial polydactyly and normal tibia. This finding indi- syndactyly, have been localized very close to each other on mouse cates that the variation in the phenotype of the original Hx mutant Chromosome (Chr) 5p (Green 1989; Mouse Genome Database is most likely caused by the presence of genetic modifiers
Mammalian Genome – Springer Journals
Published: Jan 1, 2001
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