Hematobiochemical Disturbances and Oxidative Stress After Subacute Manganese Chloride Exposure and Potential Protective Effects of Ebselen in Rats

Hematobiochemical Disturbances and Oxidative Stress After Subacute Manganese Chloride Exposure... The present study aimed to detect the possible disturbances induced by subacute exposure to manganese chloride (MnCl )on some biomarkers of hematology, clinical chemistry and oxidative stress, serum iron homeostasis, and ferritin status beside the histopathological alterations in hepatic and renal tissues, and the potential protective effects of ebselen on the Mn toxicity were also evaluated. Forty-eight rats were divided into four groups: Group 1 was used as a control. Groups 2, 3, and 4 were administered of ebselen as a single protective dose (15 mg/kg BW) intraperitoneal, daily manganese chloride (50 mg/kg BW) orally, and ebselen plus manganese chloride, respectively. The administrations were conducted for 30 days. Blood and tissue samples were collected at the end of the treatment for various experimental tests. Results revealed that MnCl did not significantly change in erythrogram with leukocytosis and neutrophilia but significantly increased serum aminotransferases and alkaline phosphatase activities, bilirubin (total, direct, and indirect), globulins, triglycerides, total cholesterol, creatinine, urea, manganese, iron and ferritin concentrations and hepatic glutathione, renal malondialdehyde and nitric oxide levels and hepatic superoxide dismutase activity, while serum albumin, hepatic malondialdehyde, and nitric oxide concentrations were significantly decreased besides non-statistical change in serum total proteins concentration. Ebselen has http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biological Trace Element Research Springer Journals

Hematobiochemical Disturbances and Oxidative Stress After Subacute Manganese Chloride Exposure and Potential Protective Effects of Ebselen in Rats

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Life Sciences; Biochemistry, general; Biotechnology; Nutrition; Oncology
ISSN
0163-4984
eISSN
1559-0720
D.O.I.
10.1007/s12011-018-1395-x
Publisher site
See Article on Publisher Site

Abstract

The present study aimed to detect the possible disturbances induced by subacute exposure to manganese chloride (MnCl )on some biomarkers of hematology, clinical chemistry and oxidative stress, serum iron homeostasis, and ferritin status beside the histopathological alterations in hepatic and renal tissues, and the potential protective effects of ebselen on the Mn toxicity were also evaluated. Forty-eight rats were divided into four groups: Group 1 was used as a control. Groups 2, 3, and 4 were administered of ebselen as a single protective dose (15 mg/kg BW) intraperitoneal, daily manganese chloride (50 mg/kg BW) orally, and ebselen plus manganese chloride, respectively. The administrations were conducted for 30 days. Blood and tissue samples were collected at the end of the treatment for various experimental tests. Results revealed that MnCl did not significantly change in erythrogram with leukocytosis and neutrophilia but significantly increased serum aminotransferases and alkaline phosphatase activities, bilirubin (total, direct, and indirect), globulins, triglycerides, total cholesterol, creatinine, urea, manganese, iron and ferritin concentrations and hepatic glutathione, renal malondialdehyde and nitric oxide levels and hepatic superoxide dismutase activity, while serum albumin, hepatic malondialdehyde, and nitric oxide concentrations were significantly decreased besides non-statistical change in serum total proteins concentration. Ebselen has

Journal

Biological Trace Element ResearchSpringer Journals

Published: Jun 2, 2018

References

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