Hemagglutinin variants of influenza A(H1N1)pdm09 virus with reduced affinity for sialic acid receptors

Hemagglutinin variants of influenza A(H1N1)pdm09 virus with reduced affinity for sialic acid... In influenza A H1 virus, amino acids at position 190 and 225 of HA affect replication and transmission. In this study, we show that the mutation D190Y in the HA of influenza AH1N1pdm09 virus reduces the affinity of the virus for sialic acid receptors expressed at the surface of red blood cells from different species without affecting virus replication in MDCK cells. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Hemagglutinin variants of influenza A(H1N1)pdm09 virus with reduced affinity for sialic acid receptors

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Publisher
Springer Vienna
Copyright
Copyright © 2014 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-013-1934-x
Publisher site
See Article on Publisher Site

Abstract

In influenza A H1 virus, amino acids at position 190 and 225 of HA affect replication and transmission. In this study, we show that the mutation D190Y in the HA of influenza AH1N1pdm09 virus reduces the affinity of the virus for sialic acid receptors expressed at the surface of red blood cells from different species without affecting virus replication in MDCK cells.

Journal

Archives of VirologySpringer Journals

Published: May 1, 2014

References

  • Attenuation of an influenza A virus due to alteration of its hemagglutinin-neuraminidase functional balance in mice
    Gen, F; Yamada, S; Kato, K; Akashi, H; Kawaoka, Y; Horimoto, T
  • Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificities
    Stevens, J; Blixt, O; Glaser, L; Taubenberger, JK; Palese, P; Paulson, JC; Wilson, IA

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