Hemagglutination mediated by the spike protein of cell-adapted bovine torovirus

Hemagglutination mediated by the spike protein of cell-adapted bovine torovirus Bovine torovirus (BToV)-Aichi, recently isolated in cultured cells, showed hemagglutination (HA) activity, although the virus has a truncated hemagglutinin-esterase (HE) protein, judging from its gene structure, indicating the existence of another viral protein with HA activity. We examined whether the spike (S) protein possesses HA activity. A BToV antiserum used in this study, reactive to S but not to HE, inhibited HA activity. Furthermore, cells infected with BToV and those expressing S showed hemadsorption (HAD) activity, which was inhibited by the anti-BToV serum; however, HAD activity by expressed HE was not blocked. These data indicate that the S protein of BToV-Aichi is responsible for its HA activity. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Hemagglutination mediated by the spike protein of cell-adapted bovine torovirus

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Publisher
Springer Vienna
Copyright
Copyright © 2013 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-013-1636-4
Publisher site
See Article on Publisher Site

References

  • Characterization of epidemic diarrhea outbreaks associated with bovine torovirus in adult cows
    Aita, T; Kuwabara, M; Murayama, K; Sasagawa, Y; Yabe, S; Higuchi, R; Tamura, T; Miyazaki, A; Tsunemitsu, H
  • Structure, function and evolution of the hemagglutinin-esterase proteins of corona- and toroviruses
    Groot, RJ
  • Epidemiological analysis of bovine torovirus in Japan
    Ito, T; Okada, N; Fukuyama, S
  • Mutation in the cytoplasmic retrieval signal of porcine epidemic diarrhea virus spike (S) protein is responsible for enhanced fusion activity
    Shirato, K; Maejima, M; Matsuyama, S; Ujike, M; Miyazaki, A; Takeyama, N; Ikeda, H; Taguchi, F

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