Strahlenther Onkol (2018) 194:235–242 https://doi.org/10.1007/s00066-017-1220-z ORIGINAL ARTICLE Heart irradiation reduces microvascular density and accumulation of HSPA1 in mice 1 1 1 2 3,4 Anna Walaszczyk · Katarzyna Szołtysek · Karol Jelonek · Joanna Polanska ´ · Wolfgang Dörr · 3 1 5 Julia Haagen ·Piotr Widłak · Dorota Gabrys´ Received: 3 May 2017 / Accepted: 19 September 2017 / Published online: 23 October 2017 © The Author(s) 2017. This article is an open access publication. Abstract Results Reduction in MD was revealed as a long-term Purpose Improvement of radiotherapy techniques reduces effect observed 20–60 weeks after irradiation. Moreover, the exposure of normal tissues to ionizing radiation. How- a signiﬁcant and dose-dependent increase in accumulation ever, the risk of radiation-related late effects remains ele- of HSPA1, both cytoplasmic and nuclear, was observed in vated. In the present study, we investigated long-term ef- heart tissues collected 20 weeks after irradiation. We also fects of radiation on heart muscle morphology. noticed an increase in collagen deposition in hearts treated Materials and methods We established a mouse model with higher doses. to study microvascular density (MVD), deposition of col- Conclusions This study shows that some changes induced lagen ﬁbers, and changes in accumulation
Strahlentherapie und Onkologie – Springer Journals
Published: Oct 23, 2017
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