Sinus histiocytosis with massive lymphadenopathy, or Rosai-Dorfman disease, is a rare, benign type of non-Langerhans cell histiocytosis. The radiological findings are often nonspecific, potentially mimicking malignancies. The diagnosis is ultimately made based on pathology, in which the lymph nodes are characterized by a dilated subcapsular sinus filled with histiocytes that can exhibit emperipolesis. Immunohistochemically, the histiocytes are variably CD68 positive and reliably negative for CD1a. The features of head and neck sinus histiocytosis with massive lymphadenopathy are exemplified in this radiology-pathology correlation sine qua non article. Keywords Sinus histiocytosis with massive lymphadenopathy · Radiology · Pathology History was preserved in most of the lymph nodes, which were not very hypervascular. CT of the neck with contrast was also The patient is an 8-year-old male with a history of asthma performed at initial presentation and at 3 months, which who presented with progressive non-painful right neck showed generalized increase in size of the bilateral multi- swelling for several weeks. Initially, the patient experienced level cervical lymphadenopathy with associated surrounding a non-productive cough but no fevers, night sweats, weight fat stranding (Fig. 2). Except for a single right neck lymph loss, or fatigue. On physical examination, there was slightly node with central hypoattenuation, the
Head and Neck Pathology – Springer Journals
Published: May 31, 2018
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