Clin Res Cardiol (2017) 106:663–675 DOI 10.1007/s00392-017-1106-1 REVIEW 1,2,3 1,10 2 4 Winfried März · Marcus E. Kleber · Hubert Scharnagl · Timotheus Speer · 4 5 6 7 Stephen Zewinger · Andreas Ritsch · Klaus G. Parhofer · Arnold von Eckardstein · 8 9 Ulf Landmesser · Ulrich Laufs Received: 18 January 2017 / Accepted: 14 March 2017 / Published online: 24 March 2017 © The Author(s) 2017. This article is an open access publication Abstract roles in cholesterol metabolism as well as many other bio- Background While several lines of evidence prove that logical functions of HDL particles are dependent on the elevated concentrations of low-density lipoproteins (LDL) number as well as protein and lipid composition of HDL causally contribute to the development of atherosclerosis particles. They are poorly reflected by the HDL-C concen- and its clinical consequences, high-density lipoproteins tration. HDL can even exert negative vascular effects, if its are still widely believed to exert atheroprotective effects. composition is pathologically altered. High serum HDL-C Hence, HDL cholesterol (HDL-C) is in general still con- is therefore no longer regarded protective. In line with this, sidered as “good cholesterol”. Recent research, however, recent pharmacological approaches to raise HDL-C con- suggests that this might not always be the case and that
Zeitschrift für Kardiologie – Springer Journals
Published: Mar 24, 2017
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