Haplotype variation of estrogen receptor-α (ER-α) gene exon 4 in Turkish sheep breeds

Haplotype variation of estrogen receptor-α (ER-α) gene exon 4 in Turkish sheep breeds Estrogen receptor a (ERα) gene has previously been found related with sexual development and reproduction. In this study, on the basis of the sequences of human, cattle and caprine estrogen receptor α (ERα) genes, available in the GenBank database, sets of PCR primers were designed and used to amplify the ovine ERα gene exon 4 region. We identified six single nucleotide polymorphisms (SNP) in the ERα exon 4. Some variations determined for exon 4 g.43A > G, p.T43A; g.49C > T, p.L49F; g.178A > T, p.T178S led to changes in the amino acids, but no amino acid changes were determined in g.18G > C, g.27C > T, g.96G > A. These fragments were deposited in the GenBank database under accession numbers: JF262030-JF262035. It was noted in particular that White Karaman and Awassi breeds were similar to each other, whereas the Chios breed had a different variation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Haplotype variation of estrogen receptor-α (ER-α) gene exon 4 in Turkish sheep breeds

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Publisher
SP MAIK Nauka/Interperiodica
Copyright
Copyright © 2012 by Pleiades Publishing, Ltd.
Subject
Biomedicine; Human Genetics; Microbial Genetics and Genomics; Animal Genetics and Genomics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S1022795412100067
Publisher site
See Article on Publisher Site

Abstract

Estrogen receptor a (ERα) gene has previously been found related with sexual development and reproduction. In this study, on the basis of the sequences of human, cattle and caprine estrogen receptor α (ERα) genes, available in the GenBank database, sets of PCR primers were designed and used to amplify the ovine ERα gene exon 4 region. We identified six single nucleotide polymorphisms (SNP) in the ERα exon 4. Some variations determined for exon 4 g.43A > G, p.T43A; g.49C > T, p.L49F; g.178A > T, p.T178S led to changes in the amino acids, but no amino acid changes were determined in g.18G > C, g.27C > T, g.96G > A. These fragments were deposited in the GenBank database under accession numbers: JF262030-JF262035. It was noted in particular that White Karaman and Awassi breeds were similar to each other, whereas the Chios breed had a different variation.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Oct 18, 2012

References

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