Arch Virol (2009) 154:1195–1197 DOI 10.1007/s00705-009-0434-5 BRIEF REVIEW Charles H. Calisher Æ C. J. Peters Æ Richard J. Douglass Æ Amy J. Kuenzi Received: 16 February 2009 / Accepted: 12 June 2009 / Published online: 1 July 2009 Springer-Verlag 2009 Virus–host interactions vary widely, depending on the host for vertical transmission has been presented for any rodent- species and the virus, and depend on age, dose and route of hantavirus system. We believe the authors are correct in exposure in determining whether the outcome will be a all their assumptions but emphasize here that the inbred chronic host infection with viral nucleic acid (genome) in laboratory mouse strain used for their studies, bred and target organs such as brain, lung, liver or kidney, whether maintained under laboratory conditions, is an artiﬁcial host infectious virus will be excreted over time, and what the for hantavirus studies, and that under natural conditions the route of excretion will be. In regard to viruses principally transmission of hantaviruses from dam to offspring could, transmitted among rodents, dominant transmission routes and likely does, occur in complex ways and may not reﬂect may be affected by any or all of these or other variables in
Archives of Virology – Springer Journals
Published: Aug 1, 2009
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