A series of erythropoietin hormone analogues (1–9) were synthesized by a modern method, microwave-assisted modified solid-phase peptide synthesis, on polystyrene polyethylene glycol graft copolymer. Peptide 9 was cleaved from the polymer to give peptide 10. Measurement of haematological data for analogue 10 gave good results comparable with those of the original hormone. The structures of the new peptides were confirmed by amino acid analysis and use of spectroscopic evidence.
Research on Chemical Intermediates – Springer Journals
Published: Feb 15, 2013
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