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Craig Montell, Youngseok Lee (2012)
Faculty Opinions recommendation of Drosophila microbiome modulates host developmental and metabolic homeostasis via insulin signaling.
W. Wikoff, A. Anfora, Jun Liu, P. Schultz, S. Lesley, E. Peters, G. Siuzdak (2009)
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolitesProceedings of the National Academy of Sciences, 106
C. Novince, Carolyn Whittow, J. Aartun, J. Hathaway, Nicole Poulides, Michael Chavez, H. Steinkamp, Kaeleigh Kirkwood, E. Huang, C. Westwater, K. Kirkwood (2017)
Commensal Gut Microbiota Immunomodulatory Actions in Bone Marrow and Liver have Catabolic Effects on Skeletal Homeostasis in HealthScientific Reports, 7
Jing Yan, J. Herzog, Kelly Tsang, C. Brennan, Maureen Bower, W. Garrett, B. Sartor, A. Aliprantis, J. Charles (2016)
Gut microbiota induce IGF-1 and promote bone formation and growthProceedings of the National Academy of Sciences, 113
R. Britton, Regina Irwin, Darin Quach, Laura Schaefer, Jing Zhang, Taehyung Lee, N. Parameswaran, L. McCabe (2014)
Probiotic L. reuteri Treatment Prevents Bone Loss in a Menopausal Ovariectomized Mouse ModelJournal of Cellular Physiology, 229
A. Humam, T. Loh, H. Foo, A. Samsudin, N. Mustapha, I. Zulkifli, Wan Izuddin (2019)
Effects of Feeding Different Postbiotics Produced by Lactobacillus plantarum on Growth Performance, Carcass Yield, Intestinal Morphology, Gut Microbiota Composition, Immune Status, and Growth Gene Expression in Broilers under Heat StressAnimals : an Open Access Journal from MDPI, 9
S. Bashiardes, Gili Zilberman-Schapira, E. Elinav (2016)
Use of Metatranscriptomics in Microbiome ResearchBioinformatics and Biology Insights, 10
K. Kareem, T. Loh, H. Foo, H. Akit, A. Samsudin (2016)
Effects of dietary postbiotic and inulin on growth performance, IGF1 and GHR mRNA expression, faecal microbiota and volatile fatty acids in broilersBMC Veterinary Research, 12
M. Matsumoto, R. Kibe, T. Ooga, Y. Aiba, Shin Kurihara, Emiko Sawaki, Y. Koga, Y. Benno (2012)
Impact of Intestinal Microbiota on Intestinal Luminal MetabolomeScientific Reports, 2
X. Morgan, N. Segata, C. Huttenhower (2013)
Biodiversity and functional genomics in the human microbiome.Trends in genetics : TIG, 29 1
J. Qin, Ruiqiang Li, J. Raes, Manimozhiyan Arumugam, K. Burgdorf, C. Manichanh, T. Nielsen, N. Pons, F. Levenez, Takuji Yamada, D. Mende, Junhua Li, Junming Xu, Shaochuan Li, Dongfang Li, Jianjun Cao, Bo Wang, Huiqing Liang, Huisong Zheng, Yinlong Xie, J. Tap, P. Lepage, Marcelo Bertalan, Jean-Michel Batto, T. Hansen, D. Paslier, A. Linneberg, H. Nielsen, É. Pelletier, P. Renault, Thomas Sicheritz-Pontén, Keith Turner, Hong-mei Zhu, Chang Yu, Shengting Li, Min Jian, Yan Zhou, Yingrui Li, Xiuqing Zhang, Songgang Li, Nan Qin, Huanming Yang, Jian Wang, S. Brunak, J. Doré, F. Guarner, K. Kristiansen, O. Pedersen, J. Parkhill, J. Weissenbach, P. Bork, S. Ehrlich, Jun Wang (2010)
A human gut microbial gene catalogue established by metagenomic sequencingNature, 464
C. Camacho‐Hübner, K. Woods, F. Miraki-Moud, A. Clark, M. Savage (1999)
Insulin-like growth factor-I deficiency caused by a partial deletion of the IGF-I gene: Effects of rhIGFmi therapyGrowth Hormone & Igf Research, 9
M. Avella, A. Place, S. Du, E. Williams, S. Silvi, Y. Zohar, O. Carnevali (2012)
Lactobacillus rhamnosus Accelerates Zebrafish Backbone Calcification and Gonadal Differentiation through Effects on the GnRH and IGF SystemsPLoS ONE, 7
Nicholas Arpaia, Clarissa Campbell, Xiying Fan, Stanislav Dikiy, J. Veeken, P. Deroos, Hui Liu, J. Cross, K. Pfeffer, P. Coffer, A. Rudensky (2013)
Metabolites produced by commensal bacteria promote peripheral regulatory T cell generationNature, 504
SC Shin, SH Kim, H You, B Kim, AC Kim, KA Lee, JH Yoon, JH Ryu, WJ Lee (2011)
Drosophila microbiome modulates host developmental and metabolic homeostasis via insulin signalingScience, 334
T. Dechiara, A. Efstratiadis, Elizabeth Robertsen (1990)
A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targetingNature, 345
R. Basu, J. Kopchick (2019)
The effects of growth hormone on therapy resistance in cancerCancer Drug Resistance, 2
S. Fang, Xuan Chen, Liwen Zhou, Chongchong Wang, Qiaohui Chen, R. Lin, T. Xiao, Q. Gan (2019)
Faecal microbiota and functional capacity associated with weaning weight in meat rabbitsMicrobial Biotechnology, 12
G. Clarke, R. Stilling, P. Kennedy, C. Stanton, J. Cryan, T. Dinan (2014)
Minireview: Gut microbiota: the neglected endocrine organ.Molecular endocrinology, 28 8
M. Sheng, Xiao-dong Zhou, L. Bonewald, D. Baylink, K. Lau (2013)
Disruption of the insulin-like growth factor-1 gene in osteocytes impairs developmental bone growth in mice.Bone, 52 1
A. Schieber, Y. Lee, M. Chang, Mathias Leblanc, B. Collins, M. Downes, R. Evans, Janelle Ayres (2015)
Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signalingScience, 350
L. Guerra-Menéndez, M. Sádaba, J. Puche, J. Lavandera, L. Castro, A. Gortázar, I. Castilla-Cortázar (2013)
IGF-I increases markers of osteoblastic activity and reduces bone resorption via osteoprotegerin and RANK-ligandJournal of Translational Medicine, 11
Jeh-Ping Liu, J. Baker, Archlbald Perkins, E. Robertson, A. Efstratiadis (1993)
Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)Cell, 75
A. Cemborain, I. Castilla-Cortázar, Jorge Quiroga, B. Muguerza, A. Picardi, S. Santidrián, Jesús Prieto (1998)
Osteopenia in rats with liver cirrhosis: beneficial effects of IGF-I treatment.Journal of hepatology, 28 1
T. Postler, S. Ghosh (2017)
Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System.Cell metabolism, 26 1
SC Shin (2011)
10.1126/science.1212782Science, 334
Guisheng Zhao, M. Monier‐Faugere, M. Langub, Z. Geng, T. Nakayama, J. Pike, S. Chernausek, C. Rosen, L. Donahue, H. Malluche, J. Fagin, T. Clemens, T. Clemens (2000)
Targeted overexpression of insulin-like growth factor I to osteoblasts of transgenic mice: increased trabecular bone volume without increased osteoblast proliferation.Endocrinology, 141 7
Yongmei Wang, Alicia Menendez, Chak Fong, H. Elalieh, T. Kubota, R. Long, D. Bikle (2015)
IGF‐I Signaling in Osterix‐Expressing Cells Regulates Secondary Ossification Center Formation, Growth Plate Maturation, and Metaphyseal Formation During Postnatal Bone DevelopmentJournal of Bone and Mineral Research, 30
Yongmei Wang, S. Nishida, H. Elalieh, R. Long, B. Halloran, D. Bikle (2006)
Role of IGF‐I Signaling in Regulating OsteoclastogenesisJournal of Bone and Mineral Research, 21
S. Yakar, Jun Liu, B. Stannard, A. Butler, D. Accili, Brian Sauer, D. Leroith (1999)
Normal growth and development in the absence of hepatic insulin-like growth factor I.Proceedings of the National Academy of Sciences of the United States of America, 96 13
L. McCabe, R. Britton, N. Parameswaran (2015)
Prebiotic and Probiotic Regulation of Bone Health: Role of the Intestine and its MicrobiomeCurrent Osteoporosis Reports, 13
Patrick Smith, Michael Howitt, Nicolai Panikov, M. Michaud, C. Gallini, Mohammad Bohlooly-Y, Jonathan Glickman, Wendy Garrett (2013)
The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell HomeostasisScience, 341
F. Hildebrand, Thi Nguyen, B. Brinkman, Roberto Yunta, Bénédicte Cauwe, P. Vandenabeele, A. Liston, J. Raes (2013)
Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory miceGenome Biology, 14
Gilles Storelli, A. Defaye, B. Erkosar, P. Hols, J. Royet, F. Leulier (2011)
Lactobacillus plantarum promotes Drosophila systemic growth by modulating hormonal signals through TOR-dependent nutrient sensing.Cell metabolism, 14 3
J. Baker, Jeh-Ping Liu, E. Robertson, A. Efstratiadis (1993)
Role of insulin-like growth factors in embryonic and postnatal growthCell, 75
Jing Yan, J. Charles (2017)
Gut Microbiome and Bone: to Build, Destroy, or Both?Current Osteoporosis Reports, 15
S Yakar (2002)
10.1172/JCI0215463J Clin Invest, 110
S. Coeverden, J. Netelenbos, C. Ridder, J. Roos, C. Popp‐Snijders, H. Waal (2002)
Bone metabolism markers and bone mass in healthy pubertal boys and girlsClinical Endocrinology, 57
Hemi Luan, Xian Wang, Z. Cai (2019)
Mass spectrometry-based metabolomics: Targeting the crosstalk between gut microbiota and brain in neurodegenerative disorders.Mass spectrometry reviews, 38 1
Jing Yan, A. Takakura, K. Zandi‐Nejad, J. Charles (2018)
Mechanisms of gut microbiota-mediated bone remodelingGut Microbes, 9
Yongmei Wang, Zhiqiang Cheng, H. Elalieh, Eiichiro Nakamura, Minh-Thanh Nguyen, S. Mackem, T. Clemens, D. Bikle, Wenhan Chang (2011)
IGF‐1R signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathwayJournal of Bone and Mineral Research, 26
Yongmei Wang, S. Nishida, B. Boudignon, A. Burghardt, H. Elalieh, M. Hamilton, S. Majumdar, B. Halloran, T. Clemens, D. Bikle (2007)
IGF‐I Receptor Is Required for the Anabolic Actions of Parathyroid Hormone on BoneJournal of Bone and Mineral Research, 22
S. Yakar, C. Rosen, W. Beamer, C. Ackert-Bicknell, Yiping Wu, Jun-li Liu, G. Ooi, Jennifer Setser, J. Frystyk, Y. Boisclair, D. Leroith (2002)
Circulating levels of IGF-1 directly regulate bone growth and density.The Journal of clinical investigation, 110 6
N. Klöting, Linda Koch, T. Wunderlich, Matthias Kern, K. Ruschke, W. Krone, J. Brüning, M. Blüher (2008)
Autocrine IGF-1 Action in Adipocytes Controls Systemic IGF-1 Concentrations and GrowthDiabetes, 57
A. Koh, F. Vadder, P. Kovatcheva-Datchary, F. Bäckhed (2016)
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial MetabolitesCell, 165
Jau-yi Li, B. Chassaing, A. Tyagi, Chiara Vaccaro, Tao Luo, Jonathan Adams, T. Darby, M. Weitzmann, J. Mulle, A. Gewirtz, Rheinallt Jones, R. Pacifici (2016)
Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics.The Journal of clinical investigation, 126 6
Mei Zhang, S. Xuan, M. Bouxsein, D. Stechow, N. Akeno, M. Faugere, H. Malluche, Guisheng Zhao, C. Rosen, A. Efstratiadis, T. Clemens (2002)
Osteoblast-specific Knockout of the Insulin-like Growth Factor (IGF) Receptor Gene Reveals an Essential Role of IGF Signaling in Bone Matrix Mineralization*The Journal of Biological Chemistry, 277
M. Schwarzer, Kassem Makki, Gilles Storelli, I. Machuca‐Gayet, D. Šrůtková, P. Hermanová, M. Martino, Séverine Balmand, T. Hudcovic, A. Heddi, J. Rieusset, H. Kozakova, H. Vidal, F. Leulier (2016)
Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutritionScience, 351
J. Wyk, Eric Smith (1999)
Insulin-like growth factors and skeletal growth: possibilities for therapeutic interventions.The Journal of clinical endocrinology and metabolism, 84 12
P. Fazeli, A. Klibanski (2014)
Determinants of GH resistance in malnutrition.The Journal of endocrinology, 220 3
Microbiota and their hosts have coevolved for millions of years. Microbiota are not only critical for optimal development of the host under normal physiological growth, but also important to ensure proper host development during nutrient scarcity or disease conditions. A large body of research has begun to detail the mechanism(s) of how microbiota cooperate with the host to maintain optimal health status. One crucial host pathway recently demonstrated to be modulated by microbiota is that of the growth factor insulin like growth factor 1 (IGF-1). Gut microbiota are capable of dynamically modulating circulating IGF-1 in the host, with the majority of data suggesting that microbiota induce host IGF-1 synthesis to influence growth. Microbiota-derived metabolites such as short chain fatty acids are sufficient to induce IGF-1. Whether microbiota induction of IGF-1 is mediated by the difference in growth hormone expression or the host sensitivity to growth hormone is still under investigation. This review summarizes the current data detailing the interaction between gut microbiota, IGF-1 and host development.
Calcified Tissue International – Springer Journals
Published: Jan 23, 2018
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