Keywords Guanidinyl benzothiazole Antioxidant activity DPPH assay ABTS assay Antimicrobial Introduction One of the main aims of synthetic chemistry is the development of new antimicrobial therapeutic agents. Even though many synthetic drugs are available, they have limitations in treating new diseases. Guanidine functionalities are found in a variety of natural products, either in cyclic form or as open-chain groups of pendent substituents [1–4]. In the literature, a large number of antimicrobial agents from both natural and synthetic origin have been found to possess guanidine functionalities. Guanidines are physiologically active organic compounds possess- ing a wide array of biological activities, including anticancer [5, 6], antidiabetic [7, 8], antiviral, antiinﬂammatory , antibiotic [10, 11], antileishmanial [12–20], antiprotozoal, antihistamine, and antihypertensive  properties. The three nitrogen atoms of a guanidine moiety, which make it possible to bind to various substituents, as a result of a guanidine derivative show a diverse range of biochemical behavior that can be attributed to their ﬂexible structure . In the case of drugs having low penetration through different membranes in the body, the introduction of a guanidinium group into their molecular architecture increases the ability of these molecules to cross biological barriers and
Research on Chemical Intermediates – Springer Journals
Published: Jan 29, 2016
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