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Guanidinyl benzothiazole derivatives: Synthesis and structure activity relationship studies of a novel series of potential antimicrobial and antioxidants

Guanidinyl benzothiazole derivatives: Synthesis and structure activity relationship studies of a... Keywords Guanidinyl benzothiazole  Antioxidant activity  DPPH assay  ABTS assay  Antimicrobial Introduction One of the main aims of synthetic chemistry is the development of new antimicrobial therapeutic agents. Even though many synthetic drugs are available, they have limitations in treating new diseases. Guanidine functionalities are found in a variety of natural products, either in cyclic form or as open-chain groups of pendent substituents [1–4]. In the literature, a large number of antimicrobial agents from both natural and synthetic origin have been found to possess guanidine functionalities. Guanidines are physiologically active organic compounds possess- ing a wide array of biological activities, including anticancer [5, 6], antidiabetic [7, 8], antiviral, antiinflammatory [9], antibiotic [10, 11], antileishmanial [12–20], antiprotozoal, antihistamine, and antihypertensive [21] properties. The three nitrogen atoms of a guanidine moiety, which make it possible to bind to various substituents, as a result of a guanidine derivative show a diverse range of biochemical behavior that can be attributed to their flexible structure [22]. In the case of drugs having low penetration through different membranes in the body, the introduction of a guanidinium group into their molecular architecture increases the ability of these molecules to cross biological barriers and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Guanidinyl benzothiazole derivatives: Synthesis and structure activity relationship studies of a novel series of potential antimicrobial and antioxidants

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Publisher
Springer Journals
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
DOI
10.1007/s11164-016-2454-6
Publisher site
See Article on Publisher Site

Abstract

Keywords Guanidinyl benzothiazole  Antioxidant activity  DPPH assay  ABTS assay  Antimicrobial Introduction One of the main aims of synthetic chemistry is the development of new antimicrobial therapeutic agents. Even though many synthetic drugs are available, they have limitations in treating new diseases. Guanidine functionalities are found in a variety of natural products, either in cyclic form or as open-chain groups of pendent substituents [1–4]. In the literature, a large number of antimicrobial agents from both natural and synthetic origin have been found to possess guanidine functionalities. Guanidines are physiologically active organic compounds possess- ing a wide array of biological activities, including anticancer [5, 6], antidiabetic [7, 8], antiviral, antiinflammatory [9], antibiotic [10, 11], antileishmanial [12–20], antiprotozoal, antihistamine, and antihypertensive [21] properties. The three nitrogen atoms of a guanidine moiety, which make it possible to bind to various substituents, as a result of a guanidine derivative show a diverse range of biochemical behavior that can be attributed to their flexible structure [22]. In the case of drugs having low penetration through different membranes in the body, the introduction of a guanidinium group into their molecular architecture increases the ability of these molecules to cross biological barriers and

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Jan 29, 2016

References