Keywords 1,1,3,3-Tetramethylguanidine Clorosulfonic acid Organocatalyst 4-Hydroxycoumarin Polycyclic dihydropyridine & Ahmad Shaabani firstname.lastname@example.org Faculty of Chemistry, Shahid Beheshti University, G. C., P. O. Box 19396-4716, Tehran, Iran 123 7248 A. Shaabani et al. Introduction Polycyclic 1,4-dihydropyridines due to their intriguing molecular structure and remarkable pharmacological efﬁciency [1–4] are important in discovering new bioactive compounds. This class of building blocks could treat Alzheimer’s disease (Tacripyrimedone) [5–7], open potassium channels (A-278637 and ZM244085) [8– 10], as well as show anti-tumor (I) , anti-diarrhea (II) [12, 13], and antimicrobial properties (III)  (Fig. 1). Nowadays, the combination of several functional groups in one molecule seems to be a useful tool to optimize properties of biological compounds. Coumarin, as a ‘‘privileged scaffold’’, is a well-known class of heterocyclic compounds, which is present in a variety of natural products as well as a large family of pharmaceutically important agents [15, 16]. Accordingly, their fusion to form a polycyclic fused pyridine ring may potentially provide a class of novel drug candidates with unusual biological activities. Many methods for the synthesis of fused pyridines [17–20] and dihyropyridines [21–23] have been reported. However, most of these methodologies suffer various harsh reaction conditions such as use
Research on Chemical Intermediates – Springer Journals
Published: Apr 6, 2016
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