Mammalian Genome 11, 1139–1141 (2000). DOI: 10.1007/s003350010165 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2000 Muriel T. Davisson, Kenneth R. Johnson, Roderick T. Bronson, Patricia F. Ward-Bailey, Susan A. Cook, Belinda S. Harris, Leah Rae Donahue The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA Received: 7 March 2000 / Accepted: 23 May 2000 A large number of unique genes in the mouse cause coat color Pathology. Two gri/gri mice at 7 months of age and six gri/gri dilution when mutated (MGD 2000). Some of these mutations mice at $1 year of age were anesthetized with tribromoethanol have pleiotropic effects such that the coat color dilution is asso- (Avertin, Aldrich Chemical Co., Milwaukee, WI) and fixed by ciated with lesions in other systems. For example, many mutations intracardiac perfusion with formol acid–alcohol or Bouin’s fixa- that dilute coat color also cause platelet storage pool deficiency tives after a flush of the vasculature with physiological saline. syndrome (Swank et al. 1998). Others have no obvious effect on Cross sections of paraffin-embedded brain at the levels of the systems other than pigmentation. The new mutation described here caudate nucleus, thalamus, midbrain, and cerebellum were pre- appears to be
Mammalian Genome – Springer Journals
Published: Dec 1, 2000
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