Green synthesis of 1,4-dihydropyrano[2,3-c]pyrazole derivatives using maltose as biodegradable catalyst

Green synthesis of 1,4-dihydropyrano[2,3-c]pyrazole derivatives using maltose as biodegradable... A simple and efficient method for one-pot four-component synthesis of highly functionalized 1,4-dihydropyrano[2,3-c]pyrazoles using hydrazine monohydrate or phenylhydrazine, ethyl acetoacetate, malononitrile and arylaldehydes under solvent-free, thermal conditions, with maltose as catalyst, has been developed. The reaction proceeds smoothly to generate the corresponding product. Use of non-toxic and inexpensive materials, simple and clean work-up, short reaction times, and good yields of the products are the advantages of this method. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Green synthesis of 1,4-dihydropyrano[2,3-c]pyrazole derivatives using maltose as biodegradable catalyst

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Publisher
Springer Netherlands
Copyright
Copyright © 2013 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-013-1365-z
Publisher site
See Article on Publisher Site

Abstract

A simple and efficient method for one-pot four-component synthesis of highly functionalized 1,4-dihydropyrano[2,3-c]pyrazoles using hydrazine monohydrate or phenylhydrazine, ethyl acetoacetate, malononitrile and arylaldehydes under solvent-free, thermal conditions, with maltose as catalyst, has been developed. The reaction proceeds smoothly to generate the corresponding product. Use of non-toxic and inexpensive materials, simple and clean work-up, short reaction times, and good yields of the products are the advantages of this method.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Sep 3, 2013

References

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