Green synthesis and evaluation of the antitumor activity of a novel series of 3-[4-bi-(4-fluorophenyl)methylpiperazinyl]-4-amino-5-thione-1,2,4-triazole Schiff bases

Green synthesis and evaluation of the antitumor activity of a novel series of... Fourteen novel 1,2,4-triazole Schiff bases containing the 1-[bi-(4-fluorophenyl)methyl]piperazine group were prepared, in good yield (73–85 %), in five steps starting from 1-[bi-(4-fluorophenyl)methyl]piperazine and ethyl chloroacetate, with use of microwave irradiation. The structures of the new compounds were characterized by IR spectroscopy, MS, 1H and 13C NMR spectroscopy, and elemental analysis. Assay of the newly prepared compounds for bioactivity against tumor cells revealed that the most of the compounds had good to excellent inhibitory activity against CDC25B (99.70 % inhibition). The 4-amino-5-[4-bi-(4-fluorophenyl) methylpiperazin-1-ylmethyl]-1,2,4-triazole-3-thione group was found to be beneficial group improving anti-tumor activity to some extent. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Green synthesis and evaluation of the antitumor activity of a novel series of 3-[4-bi-(4-fluorophenyl)methylpiperazinyl]-4-amino-5-thione-1,2,4-triazole Schiff bases

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Publisher
Springer Netherlands
Copyright
Copyright © 2015 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-015-2200-5
Publisher site
See Article on Publisher Site

Abstract

Fourteen novel 1,2,4-triazole Schiff bases containing the 1-[bi-(4-fluorophenyl)methyl]piperazine group were prepared, in good yield (73–85 %), in five steps starting from 1-[bi-(4-fluorophenyl)methyl]piperazine and ethyl chloroacetate, with use of microwave irradiation. The structures of the new compounds were characterized by IR spectroscopy, MS, 1H and 13C NMR spectroscopy, and elemental analysis. Assay of the newly prepared compounds for bioactivity against tumor cells revealed that the most of the compounds had good to excellent inhibitory activity against CDC25B (99.70 % inhibition). The 4-amino-5-[4-bi-(4-fluorophenyl) methylpiperazin-1-ylmethyl]-1,2,4-triazole-3-thione group was found to be beneficial group improving anti-tumor activity to some extent.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Aug 14, 2015

References

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