Green protocol for synthesis of 2,3-dihydroquinazolin-4(1H)-ones: lactic acid as catalyst under solvent-free condition

Green protocol for synthesis of 2,3-dihydroquinazolin-4(1H)-ones: lactic acid as catalyst under... 1 2 NH NH 20 mol% lactic acid NH H 1 O R R 1 2 solvent-free 70°C N O NH OAC Electronic supplementary material The online version of this article (doi:10.1007/s11164-016-2469-z) contains supplementary material, which is available to authorized users. & Nourallah Hazeri nhazeri@chem.usb.ac.ir Department of Chemistry, University of Sistan and Baluchestan, P. O. Box 98135-674, Zahedan, Iran 123 6382 S. Zhaleh et al. Keywords Green synthesis  Lactic acid  2,3-Dihydroquinazolin-4(1H)-one Solvent-free Introduction Synthesis of biologically and pharmacologically active organic compounds has drawn much attention in recent years; among them, nitrogen-containing hetero- cyclic compounds are of importance due to their applications in many biological processes as markers or messenger molecules and also their use as agrochemicals and pharmaceuticals [1, 2]. 2,3-Dihydroquinazolin-4(1H)-ones are a series of six- membered, nitrogen-containing heterocyclic compounds that display a wide spectrum of biological and pharmacological activities as well as medicinal properties including anticancer [3], antitumor [4], antibiotic [5], and antihyperten- sion action [6]. Some examples of drugs possessing quinazolinone skeleton are shown in Fig. 1. Additionally, 2,3-dihydroquinazolinones are valuable synthetic intermediates for preparation of biologically active 4(3H)-quinazolinones by oxidation [7]. Two main methods, viz. (1) condensation of aldehyde or ketone with 2-aminobenzamide and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Green protocol for synthesis of 2,3-dihydroquinazolin-4(1H)-ones: lactic acid as catalyst under solvent-free condition

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Publisher
Springer Netherlands
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2469-z
Publisher site
See Article on Publisher Site

Abstract

1 2 NH NH 20 mol% lactic acid NH H 1 O R R 1 2 solvent-free 70°C N O NH OAC Electronic supplementary material The online version of this article (doi:10.1007/s11164-016-2469-z) contains supplementary material, which is available to authorized users. & Nourallah Hazeri nhazeri@chem.usb.ac.ir Department of Chemistry, University of Sistan and Baluchestan, P. O. Box 98135-674, Zahedan, Iran 123 6382 S. Zhaleh et al. Keywords Green synthesis  Lactic acid  2,3-Dihydroquinazolin-4(1H)-one Solvent-free Introduction Synthesis of biologically and pharmacologically active organic compounds has drawn much attention in recent years; among them, nitrogen-containing hetero- cyclic compounds are of importance due to their applications in many biological processes as markers or messenger molecules and also their use as agrochemicals and pharmaceuticals [1, 2]. 2,3-Dihydroquinazolin-4(1H)-ones are a series of six- membered, nitrogen-containing heterocyclic compounds that display a wide spectrum of biological and pharmacological activities as well as medicinal properties including anticancer [3], antitumor [4], antibiotic [5], and antihyperten- sion action [6]. Some examples of drugs possessing quinazolinone skeleton are shown in Fig. 1. Additionally, 2,3-dihydroquinazolinones are valuable synthetic intermediates for preparation of biologically active 4(3H)-quinazolinones by oxidation [7]. Two main methods, viz. (1) condensation of aldehyde or ketone with 2-aminobenzamide and

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Feb 8, 2016

References

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