1 2 NH NH 20 mol% lactic acid NH H 1 O R R 1 2 solvent-free 70°C N O NH OAC Electronic supplementary material The online version of this article (doi:10.1007/s11164-016-2469-z) contains supplementary material, which is available to authorized users. & Nourallah Hazeri firstname.lastname@example.org Department of Chemistry, University of Sistan and Baluchestan, P. O. Box 98135-674, Zahedan, Iran 123 6382 S. Zhaleh et al. Keywords Green synthesis Lactic acid 2,3-Dihydroquinazolin-4(1H)-one Solvent-free Introduction Synthesis of biologically and pharmacologically active organic compounds has drawn much attention in recent years; among them, nitrogen-containing hetero- cyclic compounds are of importance due to their applications in many biological processes as markers or messenger molecules and also their use as agrochemicals and pharmaceuticals [1, 2]. 2,3-Dihydroquinazolin-4(1H)-ones are a series of six- membered, nitrogen-containing heterocyclic compounds that display a wide spectrum of biological and pharmacological activities as well as medicinal properties including anticancer , antitumor , antibiotic , and antihyperten- sion action . Some examples of drugs possessing quinazolinone skeleton are shown in Fig. 1. Additionally, 2,3-dihydroquinazolinones are valuable synthetic intermediates for preparation of biologically active 4(3H)-quinazolinones by oxidation . Two main methods, viz. (1) condensation of aldehyde or ketone with 2-aminobenzamide and
Research on Chemical Intermediates – Springer Journals
Published: Feb 8, 2016
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