The cross-aldol condensation between isatin (I) and substituted acetophenone (IIa–e) in one-pot reaction afforded 3-[2-(substituted-phenyl)-2-oxo-ethylidene]-1,3-dihydro-indol-2-one using polyethylene glycol (PEG-400) as solvent and bleaching earth clay (pH 12.5) as a catalyst at room temperature. The PEG 400, bleaching earth are recyclable green solvent and catalyst, respectively. The formed compounds were confirmed by spectral analysis. These compounds show significant antimicrobial activity.
Research on Chemical Intermediates – Springer Journals
Published: Oct 10, 2013
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