Electronic supplementary material The online version of this article (doi:10.1007/s11164-016-2814-2) contains supplementary material, which is available to authorized users. & Cheng-Wei Lü email@example.com School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, People’s Republic of China Medical College of Jinzhou Medical University, Jinzhou 121000, People’s Republic of China 123 3122 S.-J. Yü et al. Keywords Hantzsch reaction · Acridine-1,8-dione · Hexahydroquinoline · Potassium dihydrogen phosphate · Aqueous ethanol Introduction Acridine-1,8-diones (1,8-dioxodecahydroacridines) are an important class of nitrogen heterocyclic compounds containing a 1,4-dihydropyridine parent nucleus . They are the active pharmaceutical ingredients (APIs) and versatile reactive intermediates in synthetic and medical chemistry . There are many reports about them possessing a wide range of pharmaceutical activities, such as antimicrobial [3–5], antimalarial [6–8], antitumor , anticancer , antibacterial , fungicidal [12, 13], and DNA binding properties , and they are prescribed as calcium channel blockers . Their derivatives have been used in chemotherapy for the treatment of cancer [6–8] and cardiovascular diseases . In addition, acridinediones exhibit intense ﬂuorescence efﬁciency allowing them to be used as laser dyes [16–20], photo sensitizers, and initiators [21–23]. Moreover, they have attracted much interest due to their unique photochemical and electrochemical behavior [24,
Research on Chemical Intermediates – Springer Journals
Published: Nov 25, 2016
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