Green and chemoselective synthesis of pyrazolo[3,4-e][1,4]thiazepines and evaluation of their anti-infective activities

Green and chemoselective synthesis of pyrazolo[3,4-e][1,4]thiazepines and evaluation of their... A green and convenient approach to the synthesis of medicinally valuable pyrazolo[3,4-e][1,4]thiazepines via three-component reaction of appropriate aldehydes, 5-amino-3-methylpyrazole, and α-mercaptocarboxylic acids in water under sonication is described. This new protocol provides, via chemoselective synthesis, a new heptacyclic ring system instead of the expected pentacyclic ring system. Experimental simplicity, good functional group tolerance, excellent yields, short routine, and selectivity without the need of a catalyst are prominent features of this sonocatalyzed procedure. The representative compounds were screened for their in vitro anti-bacterial and anti-tubercular activities. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Green and chemoselective synthesis of pyrazolo[3,4-e][1,4]thiazepines and evaluation of their anti-infective activities

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Publisher
Springer Journals
Copyright
Copyright © 2014 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-013-1524-2
Publisher site
See Article on Publisher Site

Abstract

A green and convenient approach to the synthesis of medicinally valuable pyrazolo[3,4-e][1,4]thiazepines via three-component reaction of appropriate aldehydes, 5-amino-3-methylpyrazole, and α-mercaptocarboxylic acids in water under sonication is described. This new protocol provides, via chemoselective synthesis, a new heptacyclic ring system instead of the expected pentacyclic ring system. Experimental simplicity, good functional group tolerance, excellent yields, short routine, and selectivity without the need of a catalyst are prominent features of this sonocatalyzed procedure. The representative compounds were screened for their in vitro anti-bacterial and anti-tubercular activities.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Jan 10, 2014

References

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