Greater Curvature Plication with Duodenal–Jejunal Bypass: a Novel
Metabolic Surgery for Type 2 Diabetes Mellitus
Published online: 16 December 2017
Springer Science+Business Media, LLC, part of Springer Nature 2017
Objective The study investigated the use of great curvature plication with duodenal–jejunal bypass (GCP-DJB) in a type 2
diabetic with obesity rat model.
Methods Twenty-two Sprague-Dawley rats were given a high fat and sugar diet with subsequent intraperitoneal injection of a
small dosage of streptozotocin (30 mg/kg) and randomly assigned to either GCP-DJB (n = 12) or Sham surgery (n = 10). Body
weight, peripheral blood glucose, and fasting serum insulin were assayed, and insulin resistance index (IRI) was calculated,
before and at 1, 2, 4, and 8 weeks after surgery.
Results No differences were found in the preoperative characteristics of the two groups (P > 0.05). At week 1, the body weights
decreased significantly, but there was no significant difference between the two groups (P > 0.05).The fasting blood glucose was
significantly lower in the GCP-DJB than in the Sham group (P < 0.05), serum insulin levels were higher (P < 0.05), and IRI
began to decline (P < 0.05). From 2 to 8 weeks, the body weight of Sham group gradually recovered and continued to rise, while
the GCP-DJB group remained at a relatively lower state. Compared to the Sham group, the body weight, fasting blood glucose as
well as IRI of GCP-DJB rats had significantly decreased (P < 0.05). But, the fasting insulin concentrations had significantly
increased (P <0.05).
Conclusion This novel GCP-DJB procedure established a stable animal model for the study of metabolic surgery to treat type 2
diabetes mellitus (T2DM).
Nian-Cun Qiu, Xiao-Xia Cen, and Miao-E Liu contributed equally to this
work and should be considered as co-first authors.
Electronic supplementary material The online version of this article
(https://doi.org/10.1007/s11695-017-3057-z) contains supplementary
material, which is available to authorized users.
* Yang Wang
* Ming Qiu
Department of General Surgery, Hainan Branch of Chinese PLA
General Hospital, Sanya 572000, China
Department of General Surgery, Chang Zheng Hospital affiliated to
Second Military Medical University, Shanghai 200003, China
Key Laboratory of Reproductive Genetics, Women’s Hospital,
Zhejiang University, Zhejiang 310000, China
Department of Hepatobiliary and Pancreatic Surgical Oncology,
Chinese PLA General Hospital, Beijing 100000, China
Department of Organ Transplantation, Chang Zheng Hospital
affiliated to Second Military Medical University, Shanghai 200003,
Obesity Surgery (2018) 28:1595–1601