Gold nanorod-assisted near-infrared stimulation of bullfrog sciatic nerve

Gold nanorod-assisted near-infrared stimulation of bullfrog sciatic nerve Infrared neural stimulation (INS) is a new and developing approach for neural repair, with the advantages of being non-contact, spatially precise, and artifact-free. However, the disadvantage of infrared light is that it is difficult to stimulate deep tissue because of its weak penetrating power. Therefore, this paper introduces an improved method using near-infrared laser to stimulate bullfrog sciatic nerves because of its strong penetrating power. Meanwhile, gold nanorods (Au NRs) are injected into the nerve to increase the absorption of light. The mechanism is the instantaneous temperature rise caused by the absorption of infrared light by Au NRs. The compound muscle action potential (CMAP) associated with the irradiated sciatic nerve is recorded by a multi-channel physiological signal instrument. The peak to peak amplitude (V ) of CMAP for sciatic nerves injected with Au NRs increases pp significantly compared to the CMAP for control nerves without Au NRs. These results demonstrate INS by labeling nerves with nanoparticle exhibiting latent capacity to increase the efficiency, spatial resolution, and the neural responsivity, and especially, can increase the penetration depth and reduce the requisite radiant exposure level. . . . Keywords Enhanced infrared neural stimulation Gold nanorod Sciatic nerve Near-infrared stimulation Introduction with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Lasers in Medical Science Springer Journals

Gold nanorod-assisted near-infrared stimulation of bullfrog sciatic nerve

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Publisher
Springer London
Copyright
Copyright © 2018 by Springer-Verlag London Ltd., part of Springer Nature
Subject
Medicine & Public Health; Medicine/Public Health, general; Dentistry; Optics, Lasers, Photonics, Optical Devices; Quantum Optics
ISSN
0268-8921
eISSN
1435-604X
D.O.I.
10.1007/s10103-018-2554-1
Publisher site
See Article on Publisher Site

Abstract

Infrared neural stimulation (INS) is a new and developing approach for neural repair, with the advantages of being non-contact, spatially precise, and artifact-free. However, the disadvantage of infrared light is that it is difficult to stimulate deep tissue because of its weak penetrating power. Therefore, this paper introduces an improved method using near-infrared laser to stimulate bullfrog sciatic nerves because of its strong penetrating power. Meanwhile, gold nanorods (Au NRs) are injected into the nerve to increase the absorption of light. The mechanism is the instantaneous temperature rise caused by the absorption of infrared light by Au NRs. The compound muscle action potential (CMAP) associated with the irradiated sciatic nerve is recorded by a multi-channel physiological signal instrument. The peak to peak amplitude (V ) of CMAP for sciatic nerves injected with Au NRs increases pp significantly compared to the CMAP for control nerves without Au NRs. These results demonstrate INS by labeling nerves with nanoparticle exhibiting latent capacity to increase the efficiency, spatial resolution, and the neural responsivity, and especially, can increase the penetration depth and reduce the requisite radiant exposure level. . . . Keywords Enhanced infrared neural stimulation Gold nanorod Sciatic nerve Near-infrared stimulation Introduction with

Journal

Lasers in Medical ScienceSpringer Journals

Published: Jun 4, 2018

References

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