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MK Knowles, D Roberts, S Craig, M Sheen, SA Nadin-Davis, AI Wandeler (2009)
In vitro and in vivo genetic stability studies of a human adenovirus type 5 recombinant rabies glycoprotein vaccine (ONRAB)Vaccine, 27
FF Vasilyev, JA Lopatnikova, SV Sennikov (2013)
Optimized flow cytometry protocol for analysis of surface expression of interleukin-1 receptor types I and IICytotechnology, 65
Z Yuan, S Zhang, Y Liu, F Zhang, AR Fooks, Q Li, R Hu (2008)
A recombinant pseudorabies virus expressing rabies virus glycoprotein: safety and immunogenicity in dogsVaccine, 26
ZW Wang, L Sarmento, Y Wang, XQ Li, V Dhingra, T Tseggai, B Jiang, ZF Fu (2005)
Attenuated rabies virus activates, while pathogenic rabies virus evades, the host innate immune responses in the central nervous systemJ Virol, 79
X Yan, M Prosniak, MT Curtis, ML Weiss, M Faber, B Dietzschold, ZF Fu (2001)
Silver-haired bat rabies virus variant does not induce apoptosis in the brain of experimentally infected miceJ Neurovirol, 7
R Hu, S Zhang, AR Fooks, H Yuan, Y Liu, H Li, C Tu, X Xia, Y Xiao (2006)
Prevention of rabies virus infection in dogs by a recombinant canine adenovirus type-2 encoding the rabies virus glycoproteinMicrobes Infect, 8
JD Blanton, A Meadows, SM Murphy, J Manangan, CA Hanlon, ML Faber, B Dietzschold, CE Rupprecht (2006)
Vaccination of small Asian mongoose (Herpestes javanicus) against rabiesJ. Wildl. Dis., 42
DA Grosenbaugh, JL Maki, CE Rupprecht, DK Wall (2007)
Rabies challenge of captive striped skunks (Mephitis mephitis) following oral administration of a live vaccinia-vectored rabies vaccineJ Wildl Dis, 43
S Durr, R Mindekem, Y Kaninga, D Doumagoum Moto, MI Meltzer, P Vounatsou, J Zinsstag (2009)
Effectiveness of dog rabies vaccination programmes: comparison of owner-charged and free vaccination campaignsEpidemiol Infect, 137
B Dietzschold, WH Wunner, TJ Wiktor, AD Lopes, M Lafon, CL Smith, H Koprowski (1983)
Characterization of an antigenic determinant of the glycoprotein that correlates with pathogenicity of rabies virusProc Natl Acad Sci USA, 80
L Sarmento, XQ Li, E Howerth, AC Jackson, ZF Fu (2005)
Glycoprotein-mediated induction of apoptosis limits the spread of attenuated rabies viruses in the central nervous system of miceJ Neurovirol, 11
K Morimoto, DC Hooper, S Spitsin, H Koprowski, B Dietzschold (1999)
Pathogenicity of different rabies virus variants inversely correlates with apoptosis and rabies virus glycoprotein expression in infected primary neuron culturesJ Virol, 73
F Cliquet, M Aubert, L Sagne (1998)
Development of a fluorescent antibody virus neutralisation test (FAVN test) for the quantitation of rabies-neutralising antibodyJ Immunol Methods, 212
CE Rupprecht, CA Hanlon, J Blanton, J Manangan, P Morrill, S Murphy, M Niezgoda, LA Orciari, CL Schumacher, B Dietzschold (2005)
Oral vaccination of dogs with recombinant rabies virus vaccinesVirus Res, 111
RD Anderson, RE Haskell, H Xia, BJ Roessler, BL Davidson (2000)
A simple method for the rapid generation of recombinant adenovirus vectorsGene Ther., 7
(2009)
Human vaccinia infection after contact with a raccoon rabies vaccine bait: Pennsylvania, 2009MMWR Morb Mortal Wkly Rep, 58
T Lembo, K Hampson, MT Kaare, E Ernest, D Knobel, RR Kazwala, DT Haydon, S Cleaveland (2010)
The feasibility of canine rabies elimination in Africa: dispelling doubts with dataPLoS Negl Trop Dis, 4
H Wang, G Zhang, Y Wen, S Yang, X Xia, ZF Fu (2011)
Intracerebral administration of recombinant rabies virus expressing GM-CSF prevents the development of rabies after infection with street virusPLoS One, 6
R Hu, Q Tang, J Tang, AR Fooks (2009)
Rabies in China: an updateVector Borne Zoonotic Dis, 9
ND Mazarakis, M Azzouz, JB Rohll, FM Ellard, FJ Wilkes, AL Olsen, EE Carter, RD Barber, DF Baban, SM Kingsman, AJ Kingsman, K O’Malley, KA Mitrophanous (2001)
Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral deliveryHum Mol Genet, 10
J Blancou, MP Kieny, R Lathe, JP Lecocq, PP Pastoret, JP Soulebot, P Desmettre (1986)
Oral vaccination of the fox against rabies using a live recombinant vaccinia virusNature, 322
BA Yakobson, R King, S Amir, N Devers, N Sheichat, D Rutenberg, Z Mildenberg, D David (2006)
Rabies vaccination programme for red foxes (Vulpes vulpes) and golden jackals (Canis aureus) in Israel (1999–2004)Dev Biol (Basel), 125
I Seif, P Coulon, PE Rollin, A Flamand (1985)
Rabies virulence: effect on pathogenicity and sequence characterization of rabies virus mutations affecting antigenic site III of the glycoproteinJ Virol, 53
SA Nadin-Davis, GA Casey, AI Wandeler (1994)
A molecular epidemiological study of rabies virus in central Ontario and western QuebecJ Gen Virol, 75
TD Schmittgen, KJ Livak (2008)
Analyzing real-time PCR data by the comparative C(T) methodNat Protoc, 3
MK Knowles, SA Nadin-Davis, M Sheen, R Rosatte, R Mueller, A Beresford (2009)
Safety studies on an adenovirus recombinant vaccine for rabies (AdRG1.3-ONRAB) in target and non-target speciesVaccine, 27
C Lutze-Wallace, A Wandeler, L Prevec, M Sidhu, T Sapp, J Armstrong (1995)
Characterization of a human adenovirus 5: rabies glycoprotein recombinant vaccine reisolated from orally vaccinated skunksBiologicals, 23
R Amann, J Rohde, U Wulle, D Conlee, R Raue, O Martinon, HJ Rziha (2013)
A new rabies vaccine based on a recombinant ORF virus (parapoxvirus) expressing the rabies virus glycoproteinJ. Virol., 87
S Palusa, C Ndaluka, RA Bowen, CJ Wilusz, J Wilusz (2012)
The 3′ untranslated region of the rabies virus glycoprotein mRNA specifically interacts with cellular PCBP2 protein and promotes transcript stabilityPLoS One, 7
RL Hu, AR Fooks, SF Zhang, Y Liu, F Zhang (2008)
Inferior rabies vaccine quality and low immunization coverage in dogs (Canis familiaris) in ChinaEpidemiol Infect, 136
Z Li, J Wang, D Yuan, S Wang, J Sun, B Yi, Q Hou, Y Mao, W Liu (2015)
A recombinant canine distemper virus expressing a modified rabies virus glycoprotein induces immune responses in miceVirus Genes, 50
M Faber, ML Faber, A Papaneri, M Bette, E Weihe, B Dietzschold, MJ Schnell (2005)
A single amino acid change in rabies virus glycoprotein increases virus spread and enhances virus pathogenicityJ Virol, 79
DC Sequeira, ML Peixoto, PM Luca, J Oliveira-Ferreira, PR Antas, CM Borba (2013)
Detection of antibody to Purpureocillium lilacinum by immunofluorescent assay and flow cytometry in serum of infected C57BL/6 miceJ Immunol Methods, 396
J Li, M Faber, A Papaneri, ML Faber, JP McGettigan, MJ Schnell, B Dietzschold (2006)
A single immunization with a recombinant canine adenovirus expressing the rabies virus G protein confers protective immunity against rabies in miceVirology, 356
CN Wanjalla, EF Goldstein, C Wirblich, MJ Schnell (2012)
A role for granulocyte-macrophage colony-stimulating factor in the regulation of CD8(+) T cell responses to rabies virusVirology, 426
MP Kieny, R Lathe, R Drillien, D Spehner, S Skory, D Schmitt, T Wiktor, H Koprowski, JP Lecocq (1984)
Expression of rabies virus glycoprotein from a recombinant vaccinia virusNature, 312
TL Lentz, PT Wilson, E Hawrot, DW Speicher (1984)
Amino acid sequence similarity between rabies virus glycoprotein and snake venom curaremimetic neurotoxinsScience, 226
J Zhao, S Wang, S Zhang, Y Liu, J Zhang, F Zhang, L Mi, R Hu (2014)
Molecular characterization of a rabies virus isolate from a rabid dog in Hanzhong District, Shaanxi ProvinceChina Arch Virol, 159
The rabies virus (RABV) glycoprotein (G) is responsible for inducing neutralizing antibodies against rabies virus. Development of recombinant vaccines using the G genes from attenuated strains rather than street viruses is a regular practice. In contrast to this scenario, we generated three human adenovirus type 5 recombinants using the G genes from the vaccine strains SRV9 and Flury-LEP, and the street RABV strain BD06 (nrAd5-SRV9-G, nrAd5-Flury-LEP-G, and nrAd5-BD06-G). These recombinants were non-replicative, but could grow up to ~108 TCID50/ml in helper HEK293AD cells. Expression of the G protein was verified by immunostaining, quantitative PCR and cytometry. Animal experiments revealed that immunization with nrAd5-BD06-G can induce a higher seroconversion rate, a higher neutralizing antibody level, and a longer survival time after rabies virus challenge in mice when compared with the other two recombinants. Moreover, the expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) was significantly higher in mice immunized with nrAd5-BD06-G, which might also contribute to the increased protection. These results show that the use of street RABV G for non-replicative systems may be an alternative for developing effective recombinant rabies vaccines.
Archives of Virology – Springer Journals
Published: Jul 5, 2015
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