Glycerol assisted eco-friendly strategy for the facile synthesis of 4,4′-(arylmethylene)bis(3-methyl-1H-pyrazol-5-ols) and 2-aryl-2,3-dihydroquinazolin-4(1H)-ones under catalyst-free conditions

Glycerol assisted eco-friendly strategy for the facile synthesis of... Electronic supplementary material The online version of this article (doi:10.1007/s11164-016-2728-z) contains supplementary material, which is available to authorized users. & Appaswami Lalitha lalitha2531@yahoo.co.in Synthetic Organic Chemistry Research Laboratory, Department of Chemistry, Periyar University, Periyar Palkalai Nagar, Salem, Tamil Nadu 636011, India Department of Chemistry, Salem Sowdeswari College, Salem, Tamil Nadu 636010, India 123 1768 R. Ramesh et al. Keywords Glycerol  Catalyst-free  Bis(3-methyl-1H-pyrazol-5-ol) 2,3-Dihydroquinazolin-4(1H)-one  Green synthesis Introduction The exploration of proficient and environmentally benevolent routes for the preparation of medicinally privileged organic molecules is a central goal of synthesis research. Generally, nitrogen containing heterocycles are omnipresent in several natural and biologically active synthetic molecules [1–3], and they have emerged as core components in drug development because N-rich heterocyclic compounds often improve dissolution and can facilitate salt formation [4]. Among the variety of nitrogen heterocyclics, pyrazole and quinazolinone compounds have received considerable interest, as they are present in natural as well as synthetic pharmacologically potent molecules [5–7]. Considering the many properties of glycerol, such as a long liquid range, unique solubility for polar organic compounds, non-flammability and direct usage as a solvent, it would fit perfectly the requirements of a green solvent [8]. Due to their unique behaviours, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Glycerol assisted eco-friendly strategy for the facile synthesis of 4,4′-(arylmethylene)bis(3-methyl-1H-pyrazol-5-ols) and 2-aryl-2,3-dihydroquinazolin-4(1H)-ones under catalyst-free conditions

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Publisher
Springer Netherlands
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2728-z
Publisher site
See Article on Publisher Site

Abstract

Electronic supplementary material The online version of this article (doi:10.1007/s11164-016-2728-z) contains supplementary material, which is available to authorized users. & Appaswami Lalitha lalitha2531@yahoo.co.in Synthetic Organic Chemistry Research Laboratory, Department of Chemistry, Periyar University, Periyar Palkalai Nagar, Salem, Tamil Nadu 636011, India Department of Chemistry, Salem Sowdeswari College, Salem, Tamil Nadu 636010, India 123 1768 R. Ramesh et al. Keywords Glycerol  Catalyst-free  Bis(3-methyl-1H-pyrazol-5-ol) 2,3-Dihydroquinazolin-4(1H)-one  Green synthesis Introduction The exploration of proficient and environmentally benevolent routes for the preparation of medicinally privileged organic molecules is a central goal of synthesis research. Generally, nitrogen containing heterocycles are omnipresent in several natural and biologically active synthetic molecules [1–3], and they have emerged as core components in drug development because N-rich heterocyclic compounds often improve dissolution and can facilitate salt formation [4]. Among the variety of nitrogen heterocyclics, pyrazole and quinazolinone compounds have received considerable interest, as they are present in natural as well as synthetic pharmacologically potent molecules [5–7]. Considering the many properties of glycerol, such as a long liquid range, unique solubility for polar organic compounds, non-flammability and direct usage as a solvent, it would fit perfectly the requirements of a green solvent [8]. Due to their unique behaviours,

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Sep 16, 2016

References

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