Electronic supplementary material The online version of this article (doi:10.1007/s11164-016-2728-z) contains supplementary material, which is available to authorized users. & Appaswami Lalitha email@example.com Synthetic Organic Chemistry Research Laboratory, Department of Chemistry, Periyar University, Periyar Palkalai Nagar, Salem, Tamil Nadu 636011, India Department of Chemistry, Salem Sowdeswari College, Salem, Tamil Nadu 636010, India 123 1768 R. Ramesh et al. Keywords Glycerol Catalyst-free Bis(3-methyl-1H-pyrazol-5-ol) 2,3-Dihydroquinazolin-4(1H)-one Green synthesis Introduction The exploration of proﬁcient and environmentally benevolent routes for the preparation of medicinally privileged organic molecules is a central goal of synthesis research. Generally, nitrogen containing heterocycles are omnipresent in several natural and biologically active synthetic molecules [1–3], and they have emerged as core components in drug development because N-rich heterocyclic compounds often improve dissolution and can facilitate salt formation . Among the variety of nitrogen heterocyclics, pyrazole and quinazolinone compounds have received considerable interest, as they are present in natural as well as synthetic pharmacologically potent molecules [5–7]. Considering the many properties of glycerol, such as a long liquid range, unique solubility for polar organic compounds, non-ﬂammability and direct usage as a solvent, it would ﬁt perfectly the requirements of a green solvent . Due to their unique behaviours,
Research on Chemical Intermediates – Springer Journals
Published: Sep 16, 2016
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