Glycemic impact of non-nutritive sweeteners: a systematic review and meta-analysis of randomized controlled trials

Glycemic impact of non-nutritive sweeteners: a systematic review and meta-analysis of randomized... Background/objectives Nonnutritive sweeteners (NNSs) are zero- or low-calorie alternatives to nutritive sweeteners, such as table sugars. A systematic review and meta-analysis of randomized controlled trials was conducted to quantitatively synthesize existing scientific evidence on the glycemic impact of NNSs. Subjects/methods PubMed and Web of Science databases were searched. Two authors screened the titles and abstracts of candidate publications. The third author was consulted to resolve discrepancies. Twenty-nine randomized controlled trials, with a total of 741 participants, were included and their quality assessed. NNSs under examination included aspartame, saccharin, steviosides, and sucralose. The review followed the PRISMA guidelines. Results Meta-analysis was performed to estimate and track the trajectory of blood glucose concentrations over time after NNS consumption, and to test differential effects by type of NNS and participants’ age, weight, and disease status. In comparison with the baseline, NNS consumption was not found to increase blood glucose level, and its concentration gradually declined over the course of observation following NNS consumption. The glycemic impact of NNS consumption did not differ by type of NNS but to some extent varied by participants’ age, body weight, and diabetic status. Conclusions NNS consumption was not found to elevate blood glucose level. Future studies http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Clinical Nutrition Springer Journals

Glycemic impact of non-nutritive sweeteners: a systematic review and meta-analysis of randomized controlled trials

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Publisher
Nature Publishing Group UK
Copyright
Copyright © 2018 by Macmillan Publishers Limited, part of Springer Nature
Subject
Medicine & Public Health; Medicine/Public Health, general; Public Health; Epidemiology; Internal Medicine; Clinical Nutrition; Metabolic Diseases
ISSN
0954-3007
eISSN
1476-5640
D.O.I.
10.1038/s41430-018-0170-6
Publisher site
See Article on Publisher Site

Abstract

Background/objectives Nonnutritive sweeteners (NNSs) are zero- or low-calorie alternatives to nutritive sweeteners, such as table sugars. A systematic review and meta-analysis of randomized controlled trials was conducted to quantitatively synthesize existing scientific evidence on the glycemic impact of NNSs. Subjects/methods PubMed and Web of Science databases were searched. Two authors screened the titles and abstracts of candidate publications. The third author was consulted to resolve discrepancies. Twenty-nine randomized controlled trials, with a total of 741 participants, were included and their quality assessed. NNSs under examination included aspartame, saccharin, steviosides, and sucralose. The review followed the PRISMA guidelines. Results Meta-analysis was performed to estimate and track the trajectory of blood glucose concentrations over time after NNS consumption, and to test differential effects by type of NNS and participants’ age, weight, and disease status. In comparison with the baseline, NNS consumption was not found to increase blood glucose level, and its concentration gradually declined over the course of observation following NNS consumption. The glycemic impact of NNS consumption did not differ by type of NNS but to some extent varied by participants’ age, body weight, and diabetic status. Conclusions NNS consumption was not found to elevate blood glucose level. Future studies

Journal

European Journal of Clinical NutritionSpringer Journals

Published: May 15, 2018

References

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