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Glucocorticoids and the Risk of Peptic Ulcer Bleeding: Case–Control Analysis Based on Swiss Claims Data

Glucocorticoids and the Risk of Peptic Ulcer Bleeding: Case–Control Analysis Based on Swiss... Drug Saf (2018) 41:725–730 https://doi.org/10.1007/s40264-018-0645-3 ORIGINAL RESEARCH ARTICLE Glucocorticoids and the Risk of Peptic Ulcer Bleeding: Case–Control Analysis Based on Swiss Claims Data 1,2 3 4 4 • • • • Daphne Reinau Matthias Schwenkglenks Mathias Fru ¨ h Andri Signorell 4 1,2,5 Eva Blozik Christoph R. Meier Published online: 21 February 2018 Springer International Publishing AG, part of Springer Nature 2018 Abstract Results Patients with prior exposure to both GC and Introduction Controversy exists as to whether glucocorti- NSAIDs were five times more likely to experience PUB coids (GC) are ulcerogenic per se and may thus cause than patients who neither used GC nor NSAIDs (adjusted peptic ulcer bleeding (PUB) independent of concomitantly odds ratio [adj. OR] 4.80, 95% CI 3.55–6.71). Although the prescribed nonsteroidal anti-inflammatory drugs risk of PUB among patients who used NSAIDs without GC (NSAIDs). was increased threefold (adj. OR 3.20, 95% CI 2.59–3.95), Objective To investigate the association between GC use we observed only a moderately increased risk among and PUB with or without co-medication with NSAIDs. patients who used GC alone without NSAIDs (adj. OR Methods We conducted a case–control study using 1.63, 95% CI 1.20–2.42). administrative claims data from the Swiss health http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Drug Safety Springer Journals

Glucocorticoids and the Risk of Peptic Ulcer Bleeding: Case–Control Analysis Based on Swiss Claims Data

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-5916
eISSN
1179-1942
DOI
10.1007/s40264-018-0645-3
pmid
29468603
Publisher site
See Article on Publisher Site

Abstract

Drug Saf (2018) 41:725–730 https://doi.org/10.1007/s40264-018-0645-3 ORIGINAL RESEARCH ARTICLE Glucocorticoids and the Risk of Peptic Ulcer Bleeding: Case–Control Analysis Based on Swiss Claims Data 1,2 3 4 4 • • • • Daphne Reinau Matthias Schwenkglenks Mathias Fru ¨ h Andri Signorell 4 1,2,5 Eva Blozik Christoph R. Meier Published online: 21 February 2018 Springer International Publishing AG, part of Springer Nature 2018 Abstract Results Patients with prior exposure to both GC and Introduction Controversy exists as to whether glucocorti- NSAIDs were five times more likely to experience PUB coids (GC) are ulcerogenic per se and may thus cause than patients who neither used GC nor NSAIDs (adjusted peptic ulcer bleeding (PUB) independent of concomitantly odds ratio [adj. OR] 4.80, 95% CI 3.55–6.71). Although the prescribed nonsteroidal anti-inflammatory drugs risk of PUB among patients who used NSAIDs without GC (NSAIDs). was increased threefold (adj. OR 3.20, 95% CI 2.59–3.95), Objective To investigate the association between GC use we observed only a moderately increased risk among and PUB with or without co-medication with NSAIDs. patients who used GC alone without NSAIDs (adj. OR Methods We conducted a case–control study using 1.63, 95% CI 1.20–2.42). administrative claims data from the Swiss health

Journal

Drug Safety – Springer Journals

Published: Feb 21, 2018

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