Glucocorticoids and the Risk of Peptic Ulcer Bleeding: Case–Control Analysis Based on Swiss Claims Data

Glucocorticoids and the Risk of Peptic Ulcer Bleeding: Case–Control Analysis Based on Swiss... Drug Saf (2018) 41:725–730 https://doi.org/10.1007/s40264-018-0645-3 ORIGINAL RESEARCH ARTICLE Glucocorticoids and the Risk of Peptic Ulcer Bleeding: Case–Control Analysis Based on Swiss Claims Data 1,2 3 4 4 • • • • Daphne Reinau Matthias Schwenkglenks Mathias Fru ¨ h Andri Signorell 4 1,2,5 Eva Blozik Christoph R. Meier Published online: 21 February 2018 Springer International Publishing AG, part of Springer Nature 2018 Abstract Results Patients with prior exposure to both GC and Introduction Controversy exists as to whether glucocorti- NSAIDs were five times more likely to experience PUB coids (GC) are ulcerogenic per se and may thus cause than patients who neither used GC nor NSAIDs (adjusted peptic ulcer bleeding (PUB) independent of concomitantly odds ratio [adj. OR] 4.80, 95% CI 3.55–6.71). Although the prescribed nonsteroidal anti-inflammatory drugs risk of PUB among patients who used NSAIDs without GC (NSAIDs). was increased threefold (adj. OR 3.20, 95% CI 2.59–3.95), Objective To investigate the association between GC use we observed only a moderately increased risk among and PUB with or without co-medication with NSAIDs. patients who used GC alone without NSAIDs (adj. OR Methods We conducted a case–control study using 1.63, 95% CI 1.20–2.42). administrative claims data from the Swiss health http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Drug Safety Springer Journals

Glucocorticoids and the Risk of Peptic Ulcer Bleeding: Case–Control Analysis Based on Swiss Claims Data

Loading next page...
 
/lp/springer_journal/glucocorticoids-and-the-risk-of-peptic-ulcer-bleeding-case-control-SJh8LJtX0A
Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-5916
eISSN
1179-1942
D.O.I.
10.1007/s40264-018-0645-3
Publisher site
See Article on Publisher Site

Abstract

Drug Saf (2018) 41:725–730 https://doi.org/10.1007/s40264-018-0645-3 ORIGINAL RESEARCH ARTICLE Glucocorticoids and the Risk of Peptic Ulcer Bleeding: Case–Control Analysis Based on Swiss Claims Data 1,2 3 4 4 • • • • Daphne Reinau Matthias Schwenkglenks Mathias Fru ¨ h Andri Signorell 4 1,2,5 Eva Blozik Christoph R. Meier Published online: 21 February 2018 Springer International Publishing AG, part of Springer Nature 2018 Abstract Results Patients with prior exposure to both GC and Introduction Controversy exists as to whether glucocorti- NSAIDs were five times more likely to experience PUB coids (GC) are ulcerogenic per se and may thus cause than patients who neither used GC nor NSAIDs (adjusted peptic ulcer bleeding (PUB) independent of concomitantly odds ratio [adj. OR] 4.80, 95% CI 3.55–6.71). Although the prescribed nonsteroidal anti-inflammatory drugs risk of PUB among patients who used NSAIDs without GC (NSAIDs). was increased threefold (adj. OR 3.20, 95% CI 2.59–3.95), Objective To investigate the association between GC use we observed only a moderately increased risk among and PUB with or without co-medication with NSAIDs. patients who used GC alone without NSAIDs (adj. OR Methods We conducted a case–control study using 1.63, 95% CI 1.20–2.42). administrative claims data from the Swiss health

Journal

Drug SafetySpringer Journals

Published: Feb 21, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off