Drug Saf (2018) 41:725–730 https://doi.org/10.1007/s40264-018-0645-3 ORIGINAL RESEARCH ARTICLE Glucocorticoids and the Risk of Peptic Ulcer Bleeding: Case–Control Analysis Based on Swiss Claims Data 1,2 3 4 4 • • • • Daphne Reinau Matthias Schwenkglenks Mathias Fru ¨ h Andri Signorell 4 1,2,5 Eva Blozik Christoph R. Meier Published online: 21 February 2018 Springer International Publishing AG, part of Springer Nature 2018 Abstract Results Patients with prior exposure to both GC and Introduction Controversy exists as to whether glucocorti- NSAIDs were ﬁve times more likely to experience PUB coids (GC) are ulcerogenic per se and may thus cause than patients who neither used GC nor NSAIDs (adjusted peptic ulcer bleeding (PUB) independent of concomitantly odds ratio [adj. OR] 4.80, 95% CI 3.55–6.71). Although the prescribed nonsteroidal anti-inﬂammatory drugs risk of PUB among patients who used NSAIDs without GC (NSAIDs). was increased threefold (adj. OR 3.20, 95% CI 2.59–3.95), Objective To investigate the association between GC use we observed only a moderately increased risk among and PUB with or without co-medication with NSAIDs. patients who used GC alone without NSAIDs (adj. OR Methods We conducted a case–control study using 1.63, 95% CI 1.20–2.42). administrative claims data from the Swiss health
Drug Safety – Springer Journals
Published: Feb 21, 2018
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