Glecaprevir/pibrentasvir expands reach while reducing cost and duration of hepatitis C virus therapy

Glecaprevir/pibrentasvir expands reach while reducing cost and duration of hepatitis C virus therapy Hepatitis C virus (HCV) treatments have dramatically progressed from poorly tolerated, moderately successful interferon-based therapies to highly effective all-oral interferon-free regimens. While sustained virologic responses have significantly improved with fixed-dose combinations (FDC) of these direct-acting antivirals (DAA), cost remains high and certain populations of patients remain difficult to treat. Glecaprevir (GLE, an NS3/4A protease inhibitor) and pibrentasvir (PIB, NS5A inhibitor) were recently approved as a FDC therapy for HCV, and have expanded reach, reduced cost, and in certain populations, reduced HCV treatment duration. GLE/PIB is effective across all genotypes, and has been shown to be effective in HIV-infected patients, patients with chronic kidney disease, and Child–Pugh A-compensated cirrhosis. GLE/PIB is also effective for a shortened duration of 8 weeks in treatment-naive non-cirrhotic patients. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hepatology International Springer Journals

Glecaprevir/pibrentasvir expands reach while reducing cost and duration of hepatitis C virus therapy

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Publisher
Springer India
Copyright
Copyright © 2018 by Asian Pacific Association for the Study of the Liver
Subject
Medicine & Public Health; Hepatology; Colorectal Surgery; Surgery
ISSN
1936-0533
eISSN
1936-0541
D.O.I.
10.1007/s12072-018-9873-y
Publisher site
See Article on Publisher Site

Abstract

Hepatitis C virus (HCV) treatments have dramatically progressed from poorly tolerated, moderately successful interferon-based therapies to highly effective all-oral interferon-free regimens. While sustained virologic responses have significantly improved with fixed-dose combinations (FDC) of these direct-acting antivirals (DAA), cost remains high and certain populations of patients remain difficult to treat. Glecaprevir (GLE, an NS3/4A protease inhibitor) and pibrentasvir (PIB, NS5A inhibitor) were recently approved as a FDC therapy for HCV, and have expanded reach, reduced cost, and in certain populations, reduced HCV treatment duration. GLE/PIB is effective across all genotypes, and has been shown to be effective in HIV-infected patients, patients with chronic kidney disease, and Child–Pugh A-compensated cirrhosis. GLE/PIB is also effective for a shortened duration of 8 weeks in treatment-naive non-cirrhotic patients.

Journal

Hepatology InternationalSpringer Journals

Published: May 29, 2018

References

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