Reactions 1704, p174 - 2 Jun 2018 Flu-like symptoms and skin rash: 6 case reports In a retrospective, uncontrolled study of 13 patients, six adult patients (three men and three women) were described [ages at the time of reaction onset not clearly stated], who developed flu-like symptoms or skin rash during treatment with glatiramer acetate or interferon-β-1a [Avonex]. The patients, who had uveitis (diagnosed at 32 53 years) and multiple sclerosis (diagnosed at 21 44 years), started receiving immunomodulatory treatment with IM interferon- β-1a 30µg weekly (four patients) or SC glatiramer acetate 20mg daily (two patients). The patients received immunomodulatory therapy for 1 7.5 years. Out of the four patients receiving interferon-β-1a, two patients developed rash whereas the remaining two developed flu-like symptoms. Additionally, amongst the patients receiving glatiramer acetate, one patient developed rash and one patient developed flu-like symptoms. The patient’s treatments were continued [times to reaction onsets and outcomes not stated]. Author comment: "Six of the 13 patients (46%) in immunomodulatory therapy showed secondary effects associated with [interferon-β] or glatiramer acetate, with flu- like symptoms in 3 patients (23%) and skin rash in 3 patients." Velazquez-Villoria D, et al. Efficacy of immunomodulatory therapy with interferon-beta or glatiramer acetate on multiple sclerosis-associated uveitis. Archivos de la Sociedad Espanola de Oftalmologia 92: 273-279, No. 6, Jun 2017. Available from: URL: http://doi.org/10.1016/j.oftal.2016.11.018 [Spanish; summarised from a translation] - Spain 803323563 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
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