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Ghrelin-containing neurons in the olfactory bulb send collateralized projections into medial amygdaloid and arcuate hypothalamic nuclei: neuroanatomical study

Ghrelin-containing neurons in the olfactory bulb send collateralized projections into medial... Ghrelin, a gastrointestinal hormone, is a modulator of the sense of smell. The main source of ghrelin in the central nervous system has been mainly observed in specific populations of hypothalamic neurons. An increasing number of studies have reported ghrelin synthesis and its effect on neurons outside the hypothalamus. Ghrelin and its receptors are expressed in the olfactory bulbs and in other centres of the brain, such as the amygdala, for processing olfactory signals, pyramidal neurons of the cerebral cortex and the dorsal vagal complex of the medulla oblongata. It is known that ghrelin is involved in cognitive mechanisms and eating behaviours, in fact, its expression increases in anticipation of food intake. In order to identify the existence of centrifugal direct afferents from the main olfactory bulb to the medial amygdala and the hypothalamus arcuate nucleus, in this work we used two retrograde tracers, Dil and Fluoro Gold, and immunohistochemical procedure to visualize positive ghrelin neurons. Our paper provides neuroanatomic support for the ghrelin modulation of smell. Our results show that ghrelin neuron projections from mitral cells of bulbs can transmit olfactory information via branching connections to the amygdala and the hypothalamus. This pathway could play an important role in regulating feeding behaviour in response to odours. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Experimental Brain Research Springer Journals

Ghrelin-containing neurons in the olfactory bulb send collateralized projections into medial amygdaloid and arcuate hypothalamic nuclei: neuroanatomical study

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Biomedicine; Neurosciences; Neurology
ISSN
0014-4819
eISSN
1432-1106
DOI
10.1007/s00221-018-5298-z
Publisher site
See Article on Publisher Site

Abstract

Ghrelin, a gastrointestinal hormone, is a modulator of the sense of smell. The main source of ghrelin in the central nervous system has been mainly observed in specific populations of hypothalamic neurons. An increasing number of studies have reported ghrelin synthesis and its effect on neurons outside the hypothalamus. Ghrelin and its receptors are expressed in the olfactory bulbs and in other centres of the brain, such as the amygdala, for processing olfactory signals, pyramidal neurons of the cerebral cortex and the dorsal vagal complex of the medulla oblongata. It is known that ghrelin is involved in cognitive mechanisms and eating behaviours, in fact, its expression increases in anticipation of food intake. In order to identify the existence of centrifugal direct afferents from the main olfactory bulb to the medial amygdala and the hypothalamus arcuate nucleus, in this work we used two retrograde tracers, Dil and Fluoro Gold, and immunohistochemical procedure to visualize positive ghrelin neurons. Our paper provides neuroanatomic support for the ghrelin modulation of smell. Our results show that ghrelin neuron projections from mitral cells of bulbs can transmit olfactory information via branching connections to the amygdala and the hypothalamus. This pathway could play an important role in regulating feeding behaviour in response to odours.

Journal

Experimental Brain Research – Springer Journals

Published: May 29, 2018

References

  • The amygdala as a neurobiological target for ghrelin in rats: neuroanatomical, electrophysiological and behavioral evidence
    Alvarez-Crespo, M; Skibicka, KP; Farkas, I; Molnár, CS; Egecioglu, E; Hrabovszky, E; Liposits, Z; Dickson, SL
  • Connectivity from OR37 expressing olfactory sensory neurons to distinct cell types in the hypothalamus
    Bader, A; Klein, B; Breer, H; Strotmann, J
  • N-methyl-d-aspartate receptor-dependent plasticity within a distributed corticostriatal network mediates appetitive instrumental learning
    Baldwin, AE; Holahan, MR; Sadeghian, K; Kelley, AE
  • Localization of orexin-1 receptors to vagal afferent neurons in the rat and humans
    Burdyga, G; Lal, S; Spiller, D; Jiang, W; Thompson, D; Attwood, S; Saeed, S; Grundy, D; Varro, A; Dimaline, R; Dockray, GJ
  • Intra-amygdala infusion of the N-methyl-d-aspartate receptor antagonist AP5 impairs acquisition but not performance of discriminated approach to an appetitive CS
    Burns, LH; Everitt, BJ; Robbins, TW
  • Main and accessory olfactory bulbs and their projections in the brain anticipate feeding in food-entrained rats
    Caba, M; Pabello, M; Moreno, ML; Meza, E
  • Is ghrelin synthesized in the central nervous system?
    Cabral, A; Soto, EJL; Epelbaum, J; Perelló, M
  • Afferent and efferent connections of the cortex-amygdala transition zone in mice
    Cádiz-Moretti, B; Abellán-Álvaro, M; Pardo-Bellver, C; Martínez-García, F; Lanuza, E
  • Differential role of the hippocampus, amygdala, and dorsal raphe nucleus in regulating feeding, memory, and anxiety-like behavioral responses to ghrelin
    Carlini, VP; Varas, MM; Cragnolini, AB; Schiöth, HB; Scimonelli, TN; Barioglio, SR
  • Ghrelin-satisfying a hunger for the mechanism
    Cowley, MA; Grove, KL
  • The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
    Cowley, MA; Smith, RG; Diano, S; Tschöp, M; Pronchuk, N; Grove, KL
  • Hedonic and incentive signals for body weight control
    Egecioglu, E; Skibicka, KP; Hansson, C; Alvarez-Crespo, M; Friberg, PA; Jerlhag, E; Engel, JA; Dickson, SL
  • Ghrelin in central neurons
    Ferrini, F; Salio, C; Lossi, L; Merighi, A
  • Hypothalamus-olfactory system crosstalk: orexin A immunostaining in mice
    Gascuel, J; Lemoine, A; Rigault, C; Datiche, F; Benani, A; Penicaud, L; Lopez-Mascaraque, L
  • Directional coupling from the olfactory bulb to the hippocampus during a go/no-go odor discrimination task
    Gourévitch, B; Kay, LM; Martin, C
  • Expression of adiponectin receptor 1 in olfactory mucosa of mice
    Hass, N; Haub, H; Stevens, R; Breer, H; Schwarzenbacher, K
  • Ghrelin-containing neuron in cerebral cortex and hypothalamus linked with the DVC of brainstem in rat
    Hou, Z; Miao, Y; Gao, L; Pan, H; Zhu, S
  • The electrophysiology of feeding circuits
    Jobst, EE; Enriori, PJ; Cowley, MA
  • A direct main olfactory bulb projection to the ‘vomeronasal’ amygdala in female mice selectively responds to volatile pheromones from males
    Kang, N; Baum, MJ; Cherry, JA
  • Different profiles of main and accessory olfactory bulb mitral/tufted cell projections revealed in mice using an anterograde tracer and a whole-mount, flattened cortex preparation
    Kang, N; Baum, MJ; Cherry, JA
  • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    Kojima, M; Hosoda, H; Date, Y; Nakazato, M; Matsuo, H; Kangawa, K
  • Ghrelin-derived peptides: a link between appetite/reward, GH axis, and psychiatric disorders?
    Labarthe, A; Fiquet, O; Hassouna, R; Zizzari, P; Lanfuemey, L; Ramoz, N; Grouselle, D; Epelbaum, J; Tolle, V
  • Immunocytochemical observation of ghrelin-containing neurons in the rat arcuate nucleus
    Lu, S; Guan, J-L; Wang, Q-P; Uehara, K; Yamada, S; Goto, N; Date, Y; Nakazato, M; Kojima, M; Kangawa, K; Shioda, S
  • Hypoglossal nucleus projections to the rat masseter muscle
    Mameli, O; Stanzani, S; Russo, A; Pellitteri, R; Spatuzza, M; Caria, MA
  • Evidence for a trigeminal mesencephalic hypoglossal nuclei loop involved in controlling vibrissae movements in the rat. Exp
    Mameli, O; Caria, MA; Pellitteri, R; Russo, A; Saccone, S; Stanzani, S
  • Interactions between neurons in the amygdala and hypothalamus during conditioned reflex behavior involving choice of reinforcement quality in cats
    Merzhanova, GK; Dolbakya, EE; Khokhlova, VN
  • Ghrelin
    Müller, TD; Nogueiras, R; Andermann, ML
  • Ghrelin in the CNS: From hunger to a rewarding and memorable meal?
    Olszewski, PK; Schiöth, HB; Levine, AS
  • The rat brain in stereotaxic coordinates
    Paxinos, G; Watson, C
  • Reciprocal connections between the amygdala and the hippocampal formation, perirhinal cortex, and postrhinal cortex in rat. A review
    Pitkänen, A; Pikkarainen, M; Nurminen, N; Ylinen, A
  • Olfactory projections to the hypothalamus
    Price, JL; Slotnick, BM; Revial, MF
  • Convergence of olfactory and vomeronasal projections in the rat basal telencephalon
    Pro-Sistiaga, P; Mohedano-Moriano, A; Ubeda-Banon, I; Del Mar Arroyo-Jimenez, M; Marcos, P; Artacho-Perula, E; Crespo, C; Insausti, R; Martinez-Marcos, A
  • Hippocampal Ghrelin-positive neurons directly project to arcuate hypothalamic and medial amygdaloid nuclei. Could they modulate food-intake?
    Russo, C; Russo, A; Pellitteri, R; Stanzani, S
  • The need to feed: homeostatic and hedonic control of eating
    Saper, CB; Chou, TC; Elmquist, JK
  • Molecular forms of hypothalamic ghrelin and its regulation by fasting and 2-deoxy-d-glucose administration
    Sato, T; Fukue, Y; Teranishi, H; Yoshida, Y; Kojima, M
  • Modulation of spontaneous and odorant-evoked activity of rat olfactory sensory neurons by two anorectic peptides, insulin and leptin
    Savigner, A; Duchamp-Viret, P; Grosmaitre, X; Chaput, M; Garcia, S; Ma, M; Palouzier-Paulignan, B
  • Smell images and the flavour system in the human brain
    Shepherd, GM
  • Ghrelin and food reward: the story of potential underlying substrates
    Skibicka, KP; Dickson, SL
  • Perceptual and brain response to odors is associated with body mass index and postprandial total ghrelin reactivity to a meal
    Sun, X; Veldhuizen, MG; Babbs, AE; Sinha, R; Small, DM
  • Ghrelin enhances olfactory sensitivity and exploratory sniffing in rodents and humans
    Tong, J; Mannea, E; Aime, P; Pfluger, PT; Yi, C; Castaneda, TR; Davis, HW; Ren, X; Pixley, S; Benoit, S; Julliard, K; Woods, SC; Horvath, TL; Sleeman, MM; D’Alessio, D; Obici, S; Frank, R; Tschöp, MH
  • Role of intraamygdaloid acylated-ghrelin in spatial learning
    Tóth, K; László, K; Lénárd, L
  • Ghrelin, leptin and adiponectin as possible predictors of the hedonic value of odors
    Trellakis, S; Tagay, S; Fischer, C; Rydleuskaya, A; Scherag, A; Bruderek, K; Schlegl, S; Greve, J; Canbay, AE; Lang, S; Brandau, S
  • Peripheral ghrelin selectively increases Fos expression in neuropeptide Y-synthesizing neurons in mouse hypothalamic arcuate nucleus
    Wang, L; Saint-Pierre, DH; Tache, Y
  • Olfactory inputs to hypothalamic neurons controlling reproduction and fertility
    Yoon, H; Enquist, LW; Dulac, C
  • Expression of ghrelin receptor mRNA in the rat and the mouse brain
    Zigman, JM; Jones, JE; Lee, CE; Saper, CB; Elmquist, JK