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Genotyping of hepatitis B virus isolates from Lahaul and Spiti district in Himachal Pradesh, India

Genotyping of hepatitis B virus isolates from Lahaul and Spiti district in Himachal Pradesh, India Hepatitis B virus (HBV) has several genotypes. In the Indian population, genotypes A and D are the most frequent. HBV infection is hyper-endemic in the Lahaul and Spiti district in Himachal Pradesh; however, the virus genotype in this area is not known. We sequenced a 398-nucleotide segment of HBV genome that included parts of pre-S1/S2 and polymerase genes from 17 specimens from this district, and assigned a viral genotype to these. Of the 17 specimens studied, 13 (76% [95% confidence interval = 50–92%]) showed the presence of genotype C HBV; the remaining four were genotype D (n = 4; 24%) HBV. Prevalence of genotype C HBV was much higher in the district than in other parts of India. This may reflect the historical mixing of this population with that in China. Since genotype C has a higher risk of chronicity and mother-to-child transmission, prevention of HBV infection may need particular emphasis in this area. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Indian Journal of Gastroenterology Springer Journals

Genotyping of hepatitis B virus isolates from Lahaul and Spiti district in Himachal Pradesh, India

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Indian Society of Gastroenterology
Subject
Medicine & Public Health; Gastroenterology; Hepatology
ISSN
0254-8860
eISSN
0975-0711
DOI
10.1007/s12664-018-0854-9
pmid
29855856
Publisher site
See Article on Publisher Site

Abstract

Hepatitis B virus (HBV) has several genotypes. In the Indian population, genotypes A and D are the most frequent. HBV infection is hyper-endemic in the Lahaul and Spiti district in Himachal Pradesh; however, the virus genotype in this area is not known. We sequenced a 398-nucleotide segment of HBV genome that included parts of pre-S1/S2 and polymerase genes from 17 specimens from this district, and assigned a viral genotype to these. Of the 17 specimens studied, 13 (76% [95% confidence interval = 50–92%]) showed the presence of genotype C HBV; the remaining four were genotype D (n = 4; 24%) HBV. Prevalence of genotype C HBV was much higher in the district than in other parts of India. This may reflect the historical mixing of this population with that in China. Since genotype C has a higher risk of chronicity and mother-to-child transmission, prevention of HBV infection may need particular emphasis in this area.

Journal

Indian Journal of Gastroenterology – Springer Journals

Published: Jun 1, 2018

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