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Genotype analysis of ORF 62 identifies varicella-zoster virus infections caused by a vaccine strain in children

Genotype analysis of ORF 62 identifies varicella-zoster virus infections caused by a vaccine... This study was performed to differentiate vaccine-type strains from wild-type strains and determine the genotype of varicella-zoster virus (VZV) in 51 Korean children. A sequencing analysis of ORF 62 identified two cases of herpes zoster caused by the vaccine-type virus, without a previous history of varicella, 22 months and 5 months after VZV vaccination. The wild-type strain was identified in the remaining children. A genotype analysis of ORF 22 amino acids revealed genotype J in all children except one. Genotype E was identified in an infant with varicella imported from Egypt. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Genotype analysis of ORF 62 identifies varicella-zoster virus infections caused by a vaccine strain in children

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References (37)

Publisher
Springer Journals
Copyright
Copyright © Springer-Verlag Wien 2017
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
DOI
10.1007/s00705-017-3276-6
pmid
28204894
Publisher site
See Article on Publisher Site

Abstract

This study was performed to differentiate vaccine-type strains from wild-type strains and determine the genotype of varicella-zoster virus (VZV) in 51 Korean children. A sequencing analysis of ORF 62 identified two cases of herpes zoster caused by the vaccine-type virus, without a previous history of varicella, 22 months and 5 months after VZV vaccination. The wild-type strain was identified in the remaining children. A genotype analysis of ORF 22 amino acids revealed genotype J in all children except one. Genotype E was identified in an infant with varicella imported from Egypt.

Journal

Archives of VirologySpringer Journals

Published: Jun 1, 2017

Keywords: Varicella-zoster virus; Genotype; Children

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