PharmacoEconomics & Outcomes News 784, p17 - 12 Aug 2017 Genomic testing for CLL treatment not cost effective in UK The use of genomic testing to stratify patients and provide targeted treatment for chronic lymphocytic leukaemia (CLL) is not cost effective from a UK NHS perspective, according to an article in PharmacoEconomics. The authors utilised a decision-analytic model to evaluate the cost effectiveness and cost utility of genomic testing to target treatment decisions in adults with CLL in the UK. Five current and future practice strategies were evaluated which included genetic testing, no testing and genomic testing, with or without the use of ibrutinib in patients refractory to first-line treatment. Costs were reported in 2013 values with a 3.5% discount applied, and were assessed from both a UK NHS perspective and a societal perspective. Societal costs included productivity, informal care and out-of- pocket costs. Using a cost-effectiveness threshold of £30 000 per life-year or quality-adjusted-life-year (QALY) gained, the most cost-effective strategy was current genetic testing practice to stratify patients by likely response to first-line treatment without the use of ibrutinib for refractory patients. Although the future genomic testing strategies were associated with the most life-years and QALYs per patient, these strategies were not deemed cost effective when the cost-effectiveness threshold was applied. However, scenario analyses indicated that future genomic testing strategies would become cost effective if a higher threshold of £50 000 was applied, the cost of ibrutinib treatment fell or if further consideration was given to the societal costs associated with younger patients. The cost of ibrutinib treatment was noted as being the key driving factor for the cost effectiveness of the genomic testing strategies. The authors concluded that the results "suggest that stratifying patients with CLL to targeted treatment using genomic testing is not a cost-effective use of limited NHS resources, primarily owing to the high cost of ibrutinib treatment". Buchanan J, et al. Using Genomic Information to Guide Ibrutinib Treatment Decisions in Chronic Lymphocytic Leukaemia: A Cost-Effectiveness Analysis. PharmacoEconomics : 31 Jul 2017. Available from: URL: http:// dx.doi.org/10.1007/s40273-017-0519-z 803262856 1173-5503/17/0784-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved PharmacoEconomics & Outcomes News 12 Aug 2017 No. 784
PharmacoEconomics & Outcomes News – Springer Journals
Published: Aug 12, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera