Genomic structure of the human KDR/flk-1 gene

Genomic structure of the human KDR/flk-1 gene Mammalian Genome 9, 40810 (1998). Mymmafian Genome Incorporating Mouse Censure © Springer-Verlag New York Inc. 1998 Li-Yan Yin, Yaxu Wu, Carol A. Ballinger, Cam Patterson Division of Cardiology, University of Texas Medical Branch at Galveston, 301 University Boulevard, 9.138 Medical Research Building, Galveston, Texas 77555-1064, USA Received: 9 September 1997 / Accepted: 29 December 1997 Signaling by members of the receptor tyrosine kinase (RTK) gene Genomic organization of the human KDR/flk-1 gene. Our previ- ous data indicated that the KDR/flk-1 gene spanned a large seg- family is critically important in differentiation and growth of many, if not all, cell types (Ullrich and Schlessinger 1990). Vas- ment of the genome (Patterson et al. 1995). Therefore, we elected cular endothelial cells in particular are dependent on pathways to isolate P1 plasmids to facilitate the cloning and mapping of this mediated by RTKs for normal embryological development and gene. A human genomic DNA bacteriophage P1 library (Genome Systems, Inc., St. Louis, Mo.) was screened by polymerase chain proliferation. In addition to expressing non-lineage restricted reaction (PCR) with primers based on the published human KDR/ RTKs such as receptors for fibroblast growth factors, epidermal growth factor, and the platelet-derived growth factors, vascular flk-1 Mammalian Genome Springer Journals

Genomic structure of the human KDR/flk-1 gene

Loading next page...
Copyright © 1998 by Springer-Verlag
Life Sciences; Cell Biology; Anatomy; Zoology
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial