Mammalian Genome 11, 1142–1144 (2000). DOI: 10.1007/s003350010211 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2000 Genomic organization of the mouse and human a2d2 voltage-dependent calcium channel subunit genes Jane Barclay,* Michele Rees Department of Paediatrics and Child Health, Royal Free and University College Medical School, The Rayne Institute, University College London, 5 University Street, London, WC1E 6JJ, UK Received: 8 May 2000 / Accepted: 25 July 2000 2+ Changes in intracellular Ca concentration regulate a wide variety were determined by direct sequencing of the PAC clones by using 2+ of cellular function (Berridge et al. 1998). Voltage-dependent Ca Big-Dye technology (Applied Biosystems, UK). These intron sizes channels (VDCCs) are found in the plasma membranes of all ex- were estimated by Southern blot hybridization of digested PAC citable cells and are hetero-oligomeric complexes composed of up clones. Cacna2d2 is organized into 39 exons (Table 1 and Fig. 1A) to five subunits: a1, a2, d, b and g. The a1 subunit acts as a that are distributed over 85 kb of genomic DNA. Exon 1 contains channel pore, voltage sensor, and receptor for many drugs. The the start codon, and exon 39 contains the stop signal. other accessory subunits modify
Mammalian Genome – Springer Journals
Published: Dec 1, 2000
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