Genomic organization of the mouse and human α2δ2 voltage-dependent calcium channel subunit genes

Genomic organization of the mouse and human α2δ2 voltage-dependent calcium channel subunit genes Mammalian Genome 11, 1142–1144 (2000). DOI: 10.1007/s003350010211 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2000 Genomic organization of the mouse and human a2d2 voltage-dependent calcium channel subunit genes Jane Barclay,* Michele Rees Department of Paediatrics and Child Health, Royal Free and University College Medical School, The Rayne Institute, University College London, 5 University Street, London, WC1E 6JJ, UK Received: 8 May 2000 / Accepted: 25 July 2000 2+ Changes in intracellular Ca concentration regulate a wide variety were determined by direct sequencing of the PAC clones by using 2+ of cellular function (Berridge et al. 1998). Voltage-dependent Ca Big-Dye technology (Applied Biosystems, UK). These intron sizes channels (VDCCs) are found in the plasma membranes of all ex- were estimated by Southern blot hybridization of digested PAC citable cells and are hetero-oligomeric complexes composed of up clones. Cacna2d2 is organized into 39 exons (Table 1 and Fig. 1A) to five subunits: a1, a2, d, b and g. The a1 subunit acts as a that are distributed over 85 kb of genomic DNA. Exon 1 contains channel pore, voltage sensor, and receptor for many drugs. The the start codon, and exon 39 contains the stop signal. other accessory subunits modify Mammalian Genome Springer Journals

Genomic organization of the mouse and human α2δ2 voltage-dependent calcium channel subunit genes

Loading next page...
Copyright © 2000 by Springer-Verlag New York Inc.
Life Sciences; Cell Biology; Animal Genetics and Genomics; Human Genetics
Publisher site
See Article on Publisher Site

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial