Mammalian Genome 8,448~450 (1997). e//o///e 9 Springer-Vedag New York Inc. 1997 Genomic organization of the human integrin 134 gene Silvia Iacovacci, t Laurent Gagnoux-Palacios, 2 Giovanna Zambruno, 1 Guerrino Meneguzzi, 2 Marina D'Alessio 1 ILaboratory of Molecular and Cell Biology, Istituto Dermopatico dell'Immacolata, Via dei Monti di Creta 104, 00167 Rome, Italy; 2U 385 INSERM, Facult6 de M6decine, 06107 Nice Cedex 2, France Received: 20 January 1997 / Accepted: 4 February Integrin c~6134 is a member of a large family of heterodimeric display extensive disadhesion of the epithelia and decreased resis- tance to mechanical stress of the basal epithelial cells (van der receptors that mediate cell-cell and cell-extracellular matrix adhe- sion (Hynes 1992). This transmembrane protein is composed of Neut et al. 1996; Dowling et al. 1996). noncovalently linked c~6 and [34 subunits encoded by distinct To facilitate mutation analysis in JEB patients and functional genes (Hogervost et al. 1991). Both a6 and [34 polypeptides dis- studies on the integrin [34 isoforms, we have determined the struc- play a cytoplasmic domain that interacts with the cytoskeleton and ture of human ITGB4 by elucidating its exon-intron organization with signaling molecules, a transmembrane region, and a large and derived a physical
Mammalian Genome – Springer Journals
Published: Mar 24, 2009
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