Genomic organization of Ampd3, heart-type AMPD gene, located in mouse Chromosome 7

Genomic organization of Ampd3, heart-type AMPD gene, located in mouse Chromosome 7 Short Communications Mammalian Genome 8, 767–769 (1997). © Springer-Verlag New York Inc. 1997 Genomic organization of Ampd3, heart-type AMPD gene, located in mouse Chromosome 7 1 1 2 2 1 1 1 K. Sermsuvitayawong, X. Wang, A. Nagabukuro, Y. Matsuda, H. Morisaki, K. Toyama, T. Mukai, T. Morisaki Department of Bioscience, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565, Japan Laboratory of Animal Genetics, School of Agricultural Sciences, University of Nagoya, Chikusa, Nagoya 464-01, Japan Received: 12 January 1997 / Accepted: 8 June 1997 AMP deaminase (EC 3.5.4.6., AMPD), an enzyme catalyzing AMP into IMP, plays an important role in purine metabolism, especially in skeletal muscle, since metabolic myopathy associated with AMPD deficiency has been reported (Sabina and Holmes 1995). In higher eukaryotes, several isoenzymes of AMPD are encoded in separate genes (Sabina and Holmes 1995; Morisaki et al. 1990; Mahnke-Zizelman and Sabina 1992). Among three ro- dent Ampd genes, Ampd3 gene, gene for the heart-type isoform (H-isoform) of AMPD, which is expressed in heart, slow-twitch skeletal muscles and non-muscle tissues (Wang et al. 1997), has not been well studied, whereas Ampd1, encoding the M-isoform, has been extensively characterized (Morisaki et al. 1990). Under- standing the Ampd3 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

Genomic organization of Ampd3, heart-type AMPD gene, located in mouse Chromosome 7

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Publisher
Springer-Verlag
Copyright
Copyright © 1997 by Springer-Verlag New York Inc.
Subject
Life Sciences; Cell Biology; Animal Genetics and Genomics; Human Genetics
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s003359900562
Publisher site
See Article on Publisher Site

Abstract

Short Communications Mammalian Genome 8, 767–769 (1997). © Springer-Verlag New York Inc. 1997 Genomic organization of Ampd3, heart-type AMPD gene, located in mouse Chromosome 7 1 1 2 2 1 1 1 K. Sermsuvitayawong, X. Wang, A. Nagabukuro, Y. Matsuda, H. Morisaki, K. Toyama, T. Mukai, T. Morisaki Department of Bioscience, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565, Japan Laboratory of Animal Genetics, School of Agricultural Sciences, University of Nagoya, Chikusa, Nagoya 464-01, Japan Received: 12 January 1997 / Accepted: 8 June 1997 AMP deaminase (EC 3.5.4.6., AMPD), an enzyme catalyzing AMP into IMP, plays an important role in purine metabolism, especially in skeletal muscle, since metabolic myopathy associated with AMPD deficiency has been reported (Sabina and Holmes 1995). In higher eukaryotes, several isoenzymes of AMPD are encoded in separate genes (Sabina and Holmes 1995; Morisaki et al. 1990; Mahnke-Zizelman and Sabina 1992). Among three ro- dent Ampd genes, Ampd3 gene, gene for the heart-type isoform (H-isoform) of AMPD, which is expressed in heart, slow-twitch skeletal muscles and non-muscle tissues (Wang et al. 1997), has not been well studied, whereas Ampd1, encoding the M-isoform, has been extensively characterized (Morisaki et al. 1990). Under- standing the Ampd3

Journal

Mammalian GenomeSpringer Journals

Published: Oct 1, 1997

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