Genomic organization and chromosomal localization of the mouse snail (Sna) gene

Genomic organization and chromosomal localization of the mouse snail (Sna) gene Mammalian Genome 8, 686-688 (1997). 9 Springer-Verlag New York Inc. 1997 Genomic organization and chromosomal localization of the mouse snail (Sna) gene Rulang Jiang, 1 Neal G. Copeland, 2 Debra J. Gilbert, 2 Nancy A. Jenkins, 2 Thomas Gridley ~'* 1The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA 2Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA Received: 15 December 1996 / Accepted: 11 April 1997 Work in many laboratories has provided numerous examples of the conservation of genetic pathways during evolution. Although the morphogenetic changes that result in mesoderm formation vary greatly among individuals of different phyla, recent work has shown that several genes involved in mesoderm formation have been evolutionarily conserved. The Drosophila gene snail encodes Fig. 1. Genomic organization of the Sna gene. Exons are indicated by gray boxes. The region encoding the zinc fingers in exons 2 and 3 is indicated a protein with five zinc fingers (Boulay et al. 1987). snail is one of by black boxes. Enzymes: B, BgllI; N, NcoI; Nr, NruI; R, EcoRI; S, SphI; two genes required zygotically for mesoderm formation during X, Xba I. Drosophila embryogenesis. Embryos homozygous for http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

Genomic organization and chromosomal localization of the mouse snail (Sna) gene

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Publisher
Springer-Verlag
Copyright
Copyright © 1997 by Springer-Verlag
Subject
Life Sciences; Cell Biology; Anatomy; Zoology
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s003359900537
Publisher site
See Article on Publisher Site

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