Mammalian Genome 8, 686-688 (1997). 9 Springer-Verlag New York Inc. 1997 Genomic organization and chromosomal localization of the mouse snail (Sna) gene Rulang Jiang, 1 Neal G. Copeland, 2 Debra J. Gilbert, 2 Nancy A. Jenkins, 2 Thomas Gridley ~'* 1The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA 2Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA Received: 15 December 1996 / Accepted: 11 April 1997 Work in many laboratories has provided numerous examples of the conservation of genetic pathways during evolution. Although the morphogenetic changes that result in mesoderm formation vary greatly among individuals of different phyla, recent work has shown that several genes involved in mesoderm formation have been evolutionarily conserved. The Drosophila gene snail encodes Fig. 1. Genomic organization of the Sna gene. Exons are indicated by gray boxes. The region encoding the zinc fingers in exons 2 and 3 is indicated a protein with five zinc fingers (Boulay et al. 1987). snail is one of by black boxes. Enzymes: B, BgllI; N, NcoI; Nr, NruI; R, EcoRI; S, SphI; two genes required zygotically for mesoderm formation during X, Xba I. Drosophila embryogenesis. Embryos homozygous for
Mammalian Genome – Springer Journals
Published: Mar 31, 2009
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