Curr Trop Med Rep (2017) 4:95–102 DOI 10.1007/s40475-017-0111-9 MELIOIDOSIS AND TROPICAL BACTERIOLOGY (A TORRES, SECTION EDITOR) Genomic Insights Into the Melioidosis Pathogen, Burkholderia pseudomallei 1,2 2 1,2 Erin P. Price & Bart J. Currie & Derek S. Sarovich Published online: 7 July 2017 Springer International Publishing AG 2017 Abstract shift towards more detailed characterization of genetic var- Purpose of Review Genomics has fundamentally transformed iation using RNA-Seq, Methyl-Seq, and genome-wide as- our understanding of infectious diseases. Here, we provide an sociation studies will provide additional insights into this overview of the insights gained from genomic investigations fascinating and deadly bacterium. of the melioidosis-causing pathogen, Burkholderia . . pseudomallei. Keywords Burkholderia pseudomallei Genomics Recent Findings B. pseudomallei has a large and complex . . . Evolution Phylogeography Melioidosis Antibiotic genome that encodes an impressive array of virulence resistance factors, some of which are variably present. Despite fre- quent lateral gene transfer, phylogenomics resolves B. pseudomallei populations to the continental level, en- Introduction abling strain source tracing in non-endemic regions and shedding light on the origin and anthropogenic spread of The environmental saprophytic bacterium Burkholderia B. pseudomallei populations across tropical and subtrop- pseudomallei is the causative agent of the potentially life-
Current Tropical Medicine Reports – Springer Journals
Published: Jul 7, 2017
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