Genomic characterization of a cell-culture-adapted Korean human G9P(8) rotavirus, CAU05-202

Genomic characterization of a cell-culture-adapted Korean human G9P(8) rotavirus, CAU05-202 The human rotavirus G9 strain is the fifth most common rotavirus worldwide. A human rotavirus G9P(8) strain CAU05-202 was isolated from a young child with diarrhea using a cell culture system, and its major gene sequences were determined. Phylogenetic analysis of the VP7 gene revealed that CAU05-202 clustered into genetic lineage III-d and was most closely related to G9 rotaviruses from Turkey (strain GUH13) and Sri Lanka (strain 05SLC056 and 05SLC057). VP4 and NSP4 gene analysis showed that CAU05-202 belongs to the P(8)-3 lineage and genotype B, respectively. In addition, CAU05-202 has a long RNA electropherotype, supported by VP6 gene analysis, which is clearly associated with subgroup II specificity. Analysis of the G9 rotavirus strain CAU05-202 provides information concerning the genetic relationships among global rotavirus G9 strains, suggesting that closely related G9 strains are persistent and widespread in Asian countries. Archives of Virology Springer Journals

Genomic characterization of a cell-culture-adapted Korean human G9P(8) rotavirus, CAU05-202

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Springer Vienna
Copyright © 2012 by Springer-Verlag
Biomedicine; Infectious Diseases; Medical Microbiology; Virology
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