Genomic and evolutionary characterization of a novel influenza-C-like virus from swine

Genomic and evolutionary characterization of a novel influenza-C-like virus from swine We recently described the isolation of a novel influenza virus from swine exhibiting respiratory disease in the United States that is distantly related to human influenza C virus. Based on genetic, biochemical and morphological analysis, the virus was provisionally classified as C/swine/Oklahoma/1334/2011 (C/OK). To further understand the genetics and evolution of this novel pathogen, we performed a comprehensive analysis of its sequence and phylogeny. The results demonstrated that C/OK and human influenza C viruses share a conserved array of predicted functional domains in the viral RNA genome replication and viral entry machinery but vary at key functional sites. Furthermore, our evolutionary analysis showed that homologous genes of C/OK and human influenza C viruses diverged from each other an estimated several hundred to several thousand years ago. Taken together, the findings described in this study support and extend our previous observations that C/OK is a genetically and evolutionarily distinct influenza virus in the family Orthomyxoviridae . http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Genomic and evolutionary characterization of a novel influenza-C-like virus from swine

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Publisher
Springer Vienna
Copyright
Copyright © 2014 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-013-1815-3
Publisher site
See Article on Publisher Site

Abstract

We recently described the isolation of a novel influenza virus from swine exhibiting respiratory disease in the United States that is distantly related to human influenza C virus. Based on genetic, biochemical and morphological analysis, the virus was provisionally classified as C/swine/Oklahoma/1334/2011 (C/OK). To further understand the genetics and evolution of this novel pathogen, we performed a comprehensive analysis of its sequence and phylogeny. The results demonstrated that C/OK and human influenza C viruses share a conserved array of predicted functional domains in the viral RNA genome replication and viral entry machinery but vary at key functional sites. Furthermore, our evolutionary analysis showed that homologous genes of C/OK and human influenza C viruses diverged from each other an estimated several hundred to several thousand years ago. Taken together, the findings described in this study support and extend our previous observations that C/OK is a genetically and evolutionarily distinct influenza virus in the family Orthomyxoviridae .

Journal

Archives of VirologySpringer Journals

Published: Feb 1, 2014

References

  • Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus
    He, XJ; Zhou, J; Bartlam, M; Zhang, RG; Ma, JY; Lou, ZY; Li, XM; Li, JJ; Joachimiak, A; Zeng, ZH; Ge, RW; Rao, ZH; Liu, YF
  • Continued circulation of reassortant H1N2 influenza viruses in pigs in Japan
    Ito, T; Kawaoka, Y; Vines, A; Ishikawa, H; Asai, T; Kida, H
  • A combined transmembrane topology and signal peptide prediction method
    Kall, L; Krogh, A; Sonnhammer, EL
  • Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes
    Krogh, A; Larsson, B; Heijne, G; Sonnhammer, EL

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